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三果木成分水醇提取物对多重耐药性尿路致病性细菌的抗菌潜力——初步报告

Antibacterial potential of hydroalcoholic extracts of triphala components against multidrug-resistant uropathogenic bacteria--a preliminary report.

作者信息

Bag Anwesa, Bhattacharyya Subir Kumar, Pal Nishith Kumar

机构信息

Department of Microbiology, Institute of Post Graduate Medical Education and Research, 244, AJC Bose Road, Kolkata 700 020, India.

出版信息

Indian J Exp Biol. 2013 Sep;51(9):709-14.

Abstract

"Triphala", the Ayurvedic wonder is used traditionally for the treatment of different types of diseases since antiquity. The hydroalcoholic extracts of the three components of Triphala powder demonstrated varying degrees of strain specific antibacterial activity against multidrug-resistant uropathogenic bacteria. Terminalia chebula fruit extract was active against all the test isolates followed by Terminalia belerica and Emblica officinalis. There was a close association between antibacterial activity and total phenolic content of Triphala components.The test plant extracts were also found to be non-toxic on human erythrocyte membrane at recommended and even higher doses. The preliminary results of the present study may help in developing effective and safe antimicrobial agents from Triphala components for the treatment of urinary tract infections caused by multidrug-resistant bacteria.

摘要

“三果木”,这种阿育吠陀的神奇药物自古以来就被传统用于治疗各种疾病。三果木粉三种成分的水醇提取物对多重耐药性尿路致病性细菌表现出不同程度的菌株特异性抗菌活性。诃子果实提取物对所有测试分离株均有活性,其次是毗黎勒和余甘子。三果木成分的抗菌活性与总酚含量之间存在密切关联。在所推荐剂量甚至更高剂量下,测试植物提取物对人体红细胞膜也无毒。本研究的初步结果可能有助于从三果木成分开发有效且安全的抗菌剂,用于治疗由多重耐药细菌引起的尿路感染。

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