Li Yang, Li Zhijie, Li Yagang, Ye Junfeng
Key Laboratory of Zoonosis, Ministry of Education, Institute of Zoonosis, Jilin University, Changchun 130062, China.
State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China.
Wei Sheng Wu Xue Bao. 2013 Sep 4;53(9):966-75.
The ClfA adhesin of Staphylococcus aureus is an excellent vaccine candidate antigen. CD4 + T cells play central roles during immune responses, but their functional contributions to Staphylococcus aureus in fection have yet to be evaluated.
By using the SYFPEITHI prediction algorithm, we identified and characterized four Th epitopes within the ClfA adhesin.
Peptide C335 was I-Ed restricted Th1 type epitopes; peptides C214, C286, and C436 were I-Ad restricted Th2 type epitope.
The identification of these epitopes is important to evaluate and optimize the vaccine-primed protection against Staphylococcus aureus infection.
金黄色葡萄球菌的ClfA黏附素是一种优良的疫苗候选抗原。CD4 + T细胞在免疫反应中起核心作用，但其在金黄色葡萄球菌感染中的功能贡献尚未得到评估。
通过使用SYFPEITHI预测算法，我们在ClfA黏附素中鉴定并表征了四个Th表位。
肽C335是I-Ed限制的Th1型表位；肽C214、C286和C436是I-Ad限制的Th2型表位。
这些表位的鉴定对于评估和优化针对金黄色葡萄球菌感染的疫苗引发的保护作用具有重要意义。
