Khaletskaia E V, Fadeeva L L, Selezneva A Iu, Semenova T B
Zh Mikrobiol Epidemiol Immunobiol. 1987 Feb(2):51-4.
The antiviral action of herpes vaccine and poludan, an interferon-inducing agent, has been studied in experimental herpes infection, and the synergic effect of these preparations has been obtained. The best result (survival rate equal to 100% after the intraperitoneal inoculation of herpes simplex virus and 85.7% after its intracerebral inoculation) has been registered after the multiple vaccination of experimental animals and the injection of poludan 1 day before the challenge of the animals with the virus. The protective effect of the synergic action of the preparations under study coincides with the period of the maximum content of antibodies in the blood sera of the animals.
疱疹疫苗和聚肌胞（一种干扰素诱导剂）的抗病毒作用已在实验性疱疹感染中进行了研究，并获得了这些制剂的协同作用效果。在对实验动物进行多次接种并在动物受到病毒攻击前1天注射聚肌胞后，取得了最佳结果（单纯疱疹病毒腹腔接种后存活率为100%，脑内接种后为85.7%）。所研究制剂协同作用的保护效果与动物血清中抗体含量最高的时期一致。
