Barinskiĭ I F, Semenova T B, Posevaia T A, Alimbarova L M, Kolieva M Kh, Shabalina N V
Vopr Virusol. 1993 Nov-Dec;38(6):274-6.
National immunostimulators and interferon inducers (poludan, ridostin, larifan, myelopide, vegetan) in combination with a commercial herpes vaccine (HV) were used for experimental immunization of mice. A 3-fold or greater rise of specific antibody titres was observed after a single immunization of intact BALB/c mice. In experiments in chronically infected animals a single inoculation of HV resulted in a 3-fold rise of specific antibody titres at 6 days postimmunization but not in later periods (20, 30 days). Administration of larifan, an interferon inducer, but not the immunostimulator myelopide, induced a synergic effect in these experiments. Activation of alpha-interferon production was observed early after combined use of HV and immunostimulators. It is concluded that combined experimental use of HV and immunostimulators activated both specific antibody production and interferon production.
将国家免疫刺激剂和干扰素诱导剂（聚多糖、瑞多斯汀、拉里凡、髓必妥、植物聚糖）与一种商用疱疹疫苗（HV）联合用于小鼠的实验性免疫。完整的BALB/c小鼠单次免疫后，观察到特异性抗体滴度有3倍或更高的升高。在慢性感染动物的实验中，单次接种HV后，免疫后6天特异性抗体滴度升高了3倍，但在后期（20天、30天）则没有。在这些实验中，干扰素诱导剂拉里凡的给药诱导了协同效应，而免疫刺激剂髓必妥则没有。在联合使用HV和免疫刺激剂后，早期观察到α干扰素产生的激活。得出的结论是，HV和免疫刺激剂的联合实验使用激活了特异性抗体产生和干扰素产生。
