Bian Jing, Li Bo, Kou Xian-Juan, Liu Tian-Zhou, Ming Liang
Department of Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China E-mail :
Asian Pac J Cancer Prev. 2013;14(11):6241-3. doi: 10.7314/apjcp.2013.14.11.6241.
To explore the predictive value of tumor markers, including cancer antigen 72-4 (CA72-4), cancer antigen 15-3 (CA15-3) and cancer antigen 125 (CA125), in single or combined detection, for the diagnosis of ovarian cancer.
120 patients diagnosed with ovarian cancer from August 2011 to March 2013 and 80 patients diagnosed with benign ovarian tumors were enrolled in this test, along with 50 health examination women randomly selected from the database as controls. Serum levels of CA72-4, CA15-3 and CA125 in this study were determined by electrochemiluminescence (ECL).
Serum levels of CA72-4, CA15-3 and CA125 in ovarian cancer were higher than those in healthy group and benign group (P<0.01).The sensitivity of combined detection of those three tumor markers for diagnosis of ovarian cancer was obviously higher than with single detection with each marker (P<0.01).
CA72-4, CA15-3 and CA125 could be a good combination in the diagnosis of ovarian cancer. Patients whose tumor markers continue to increase should be highly suspected of malignancy.
探讨肿瘤标志物癌抗原72-4（CA72-4）、癌抗原15-3（CA15-3）和癌抗原125（CA125）单独或联合检测对卵巢癌诊断的预测价值。
选取2011年8月至2013年3月确诊为卵巢癌的120例患者、确诊为卵巢良性肿瘤的80例患者，以及从数据库中随机选取的50例健康体检女性作为对照。本研究采用电化学发光法（ECL）测定血清CA72-4、CA15-3和CA125水平。
卵巢癌患者血清CA72-4、CA15-3和CA125水平高于健康组和良性组（P<0.0１）。这三种肿瘤标志物联合检测诊断卵巢癌的灵敏度明显高于各标志物单独检测（P<0.0１）。
CA72-4、CA15-3和CA125联合检测对卵巢癌诊断有较好的价值。肿瘤标志物持续升高的患者应高度怀疑为恶性肿瘤。
