Kong Feng, Han Xue-Ying, Luan Yun, Qi Tong-Gang, Sun Chao, Wang Jue, Hou Hua-Ying, Jiang Yu-Hua, Zhao Jing-Jie, Cheng Guang-Hui
Central Research Laboratory, The Second Hospital of Shandong University, Jinan, China E-mail : chenggh2008@aliyun. com,
Asian Pac J Cancer Prev. 2013;14(11):6411-3. doi: 10.7314/apjcp.2013.14.11.6411.
Adenocarcinoma of esophagus (AE) is a complex disease, affected by a variety of genetic and environmental factors. Much evidence has shown that the MutY glycosylase homologue (MUTYH) plays a key role in the pathogenesis of many cancers. However, there have been no reports on influence on AE in the Han Chinese population. The objective of this study was to investigate this issue. A gene-based association study was conducted using three single nucleotide polymorphisms(SNPs) reported in previous studies. The three SNPs (rs3219463, rs3219472, rs3219489) were genotyped in 207 unrelated AE patients and 249 healthy controls in a case-control study using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). The results revealed that the genotype distribution of rs3219472 differed between the case and control groups (OR=1.66,95%CI=1.11-2.48, P=0.012 ), indicating that an association may exist between MUTYH and AE. These findings support a signifcant role for MUTYH in AE pathogenesis in the Han Chinese population.
食管腺癌（AE）是一种复杂的疾病，受多种遗传和环境因素影响。大量证据表明，MutY糖基化酶同源物（MUTYH）在许多癌症的发病机制中起关键作用。然而，关于其对中国汉族人群AE的影响尚无报道。本研究的目的是调查这一问题。使用先前研究中报道的三个单核苷酸多态性（SNP）进行了一项基于基因的关联研究。在一项病例对照研究中，采用聚合酶链反应和限制性片段长度多态性（PCR-RFLP）对207例无亲缘关系的AE患者和249例健康对照进行了三个SNP（rs3219463、rs3219472、rs3219489）的基因分型。结果显示，病例组和对照组之间rs3219472的基因型分布存在差异（OR=1.66，95%CI=1.11-2.48，P=0.012），表明MUTYH与AE之间可能存在关联。这些发现支持MUTYH在中国汉族人群AE发病机制中起重要作用。
