Xie Ying, Wu Yuan, Zhou Xunzhao, Yao Mengwei, Ning Sisi, Wei Zhengbo
Guangxi Key Laboratory for High-Incidence Tumor Prevention and Treatment, Experimental Center of Medical Science of Guangxi Medical University, Nanning, People's Republic of China.
Graduate School of Guangxi Medical University, Nanning, People's Republic of China.
Onco Targets Ther. 2016 Feb 12;9:755-60. doi: 10.2147/OTT.S95944. eCollection 2016.
This case-control study investigates the possible relationships between the single-nucleotide polymorphisms rs1052133 in the human 8-oxoguanine DNA glycosylase 1 (hOGG1) gene and rs3219472 in the human MutY glycosylase homologue (hMUTYH) gene and the risk of nasopharyngeal carcinoma (NPC). The two polymorphisms were genotyped in 488 unrelated NPC patients and 573 cancer-free controls. Genotype GG at rs1052133 was associated with significantly lower NPC risk than genotypes GC + CC (odds ratio [OR] 0.770, 95% confidence interval [CI] 0.595-0.996, P=0.012). In subgroup analyses, subjects with genotype GG at rs1052133 were at lower risk of NPC than those with GC or CC among individuals older than 40 years (OR 0.706, 95% CI 0.524-0.950), women (OR 0.571, 95% CI 0.337-0.968), and those with no smoking history (OR 0.634, 95% CI 0.463-0.868). No significant association was seen between polymorphisms at hMUTYH rs3219472 and the risk of NPC. However, gene-gene interaction analysis showed that subjects with genotype CC at rs1052133 and genotype AA at rs3219472 (CC/AA) were at 2.887-fold higher risk of NPC than those with GG/GG, 3.183-fold higher risk than those with GG/GA, and 3.392-fold higher risk than those with GG/AA. Our results suggest that hOGG1 rs1052133 polymorphism may play an important role in NPC pathogenesis, especially among women, >40 years old, and those with no smoking history. The hMUTYH rs3219472 polymorphism may interact with hOGG1 rs1052133 polymorphism to influence susceptibility to NPC.
这项病例对照研究调查了人类8-氧代鸟嘌呤DNA糖基化酶1（hOGG1）基因中的单核苷酸多态性rs1052133和人类MutY糖基化酶同源物（hMUTYH）基因中的rs3219472与鼻咽癌（NPC）风险之间的可能关系。在488名无亲属关系的NPC患者和573名无癌对照中对这两种多态性进行了基因分型。rs1052133位点的GG基因型与NPC风险显著低于GC + CC基因型相关（优势比[OR] 0.770，95%置信区间[CI] 0.595 - 0.996，P = 0.012）。在亚组分析中，rs1052133位点基因型为GG的受试者在40岁以上个体（OR 0.706，95% CI 0.524 - 0.950）、女性（OR 0.571，95% CI 0.337 - 0.968）以及无吸烟史的个体（OR 0.634，95% CI 0.463 - 0.868）中患NPC的风险低于基因型为GC或CC的个体。未发现hMUTYH rs3219472位点的多态性与NPC风险之间存在显著关联。然而，基因 - 基因相互作用分析表明，rs1052133位点基因型为CC且rs3219472位点基因型为AA（CC/AA）的受试者患NPC的风险比GG/GG基因型的受试者高2.887倍，比GG/GA基因型的受试者高3.183倍，比GG/AA基因型的受试者高3.392倍。我们的结果表明，hOGG1 rs1052133多态性可能在NPC发病机制中起重要作用，尤其是在女性、40岁以上以及无吸烟史的人群中。hMUTYH rs3219472多态性可能与hOGG1 rs1052133多态性相互作用，影响对NPC的易感性。
