Pan Xiong-Fei, Fei Man-Dong, Zhang Kenneth Y, Fan Zhen-Lie, Fu Feng-Huan, Fan Jin-Hu
Cancer Institute and Hospital of Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China E-mail :
Asian Pac J Cancer Prev. 2014 Jan;14(11):6579-84. doi: 10.7314/apjcp.2013.14.11.6579.
With effective early treatments, many breast cancer patients suffer from psychological distress due to adverse effects and lifelong physical disfigurement. Our study aimed to evaluate the psychopathological profile of breast cancer patients in comparison with healthy women and explored demographic correlates.
We consecutively enrolled breast cancer patients who came to the hospital for follow-up or rehabilitation care after primary treatment, and healthy female relatives or friends of inpatients in the Cancer Institute of Chinese Academy of Medical Sciences between August 30, 2010 and January 1, 2012. Psychopathological profile was assessed based on the Symptom Checklist-90-R (SCL-90-R) for patients and controls. We compared demographics such as age, ethnicity, education, marriage, and occupation, and incorporated these data plus cancer status for the association with the general SCL-90-R index and scores for 9 major symptom dimensions in multiple regression analysis.
We surveyed a total of 291 female breast cancer patients and 531 healthy women. The average age was 55.1 ± 6.40 years for breast cancer patients and 43.1 ± 12.8 for healthy controls (P<0.01). The mean survival was 5.20 years for cancer patients (range, 0.60-9.90 years). There were statistically significant differences in education, marriage, and occupation between the two groups (P<0.01). General index (1.45 ± 0.45 versus 1.32 ± 0.37) and 8 dimension scores (excluding anxiety) on SCL-90-R were significantly higher in patients (P<0.05). Multiple regression analysis showed that the breast cancer status was positively correlated with general SCL-90-R index and 6 dimension scores (excluding the anxiety, phobic anxiety and paranoid ideation dimensions) (P<0.05). Regression coefficients ranged from 0.10 (depression) to 0.19 (somatization). Higher interpersonal sensitivity was noticed in single women compared to married women.
Chinese patients with breast cancer demonstrate greater psychopathology compared to healthy controls. The breast cancer status is an independent contributing factor to the general psychopathological profile. Breast cancer patients should be given particular counseling and care to alleviate their psychological distress.
尽管有有效的早期治疗方法，但许多乳腺癌患者仍因不良反应和终身身体残疾而遭受心理困扰。我们的研究旨在评估乳腺癌患者与健康女性相比的心理病理学特征，并探讨人口统计学相关因素。
我们连续招募了在2010年8月30日至2012年1月1日期间到中国医学科学院肿瘤研究所进行随访或康复护理的乳腺癌患者，以及住院患者的健康女性亲属或朋友。根据症状自评量表90修订版（SCL-90-R）对患者和对照组进行心理病理学特征评估。我们比较了年龄、种族、教育程度、婚姻状况和职业等人口统计学特征，并将这些数据以及癌症状况纳入多元回归分析，以探讨其与SCL-90-R总指数和9个主要症状维度得分的关联。
我们共调查了291名女性乳腺癌患者和531名健康女性。乳腺癌患者的平均年龄为55.1±6.40岁，健康对照组为43.1±12.8岁（P<0.01）。癌症患者的平均生存期为5.20年（范围为0.60 - 9.90年）。两组在教育程度、婚姻状况和职业方面存在统计学显著差异（P<0.01）。患者的SCL-90-R总指数（1.45±0.45对1.32±0.37）和8个维度得分（不包括焦虑）显著更高（P<0.05）。多元回归分析表明，乳腺癌状况与SCL-90-R总指数和6个维度得分（不包括焦虑、恐惧焦虑和偏执观念维度）呈正相关（P<0.05）。回归系数范围从0.10（抑郁）到0.19（躯体化）。与已婚女性相比，单身女性的人际敏感性更高。
与健康对照组相比，中国乳腺癌患者表现出更严重的心理病理学特征。乳腺癌状况是总体心理病理学特征的一个独立影响因素。应给予乳腺癌患者特别的咨询和护理，以减轻他们的心理困扰。
