Afsharfard Aboulfazl, Mozaffar Mohammad, Orang Elahe, Tahmasbpour Eisa
Department of Surgery, Shohadaye Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran E-mail :
Asian Pac J Cancer Prev. 2013;14(11):6905-11. doi: 10.7314/apjcp.2013.14.11.6905.
Breast cancer (BC) is the top cancer among women worldwide and the most frequent malignancy among Iranian women over the past few decades. The increasing trend and high mortality rate of BC in the developing world necessitates studies concentrating on its characteristics in countries in Asia. The current study focused on clinical and histopathological features of BC among Iranian females.
This retrospective study involved 714 Iranian patients with histopathologically proven BC undergoing resection of primary tumours and axillary clearance. Demographic, clinical and histopathological data were obtained and studied between ten year age groups (≤ 40 years, 41-50 years, 51-60 years, 61-70 years, and ≤ 71 years) in four chronologic phases from 1994-2009.
Mean age of patients was 49.4 ± 13.1 years. Most of cases (33.2%) were in 41-50 group. Mean size of primary tumors was 3.94 ± 2.47 cm and 87.1% of cases had infiltrative ductal carcinoma. Modified radical mastectomy was the most common method of surgery carried out (48.8%). Some 57.1% of tumors were in pT2 and tumor size decreased significantly during the period (p<0.05). The most common BC stage was llla (27%). Lower BC stages (0 and 1) constituted 13.9% of the diagnosed tumors. Our series of patients aged ≤ 40 had larger tumors (mean 4.73 ≤ 3.02 cm) compared to older age groups (p=0.003). Lower stages (0 and I) were more frequent among the oldest patients while nearly 50% of patients aged ≤ 40 had tumor stage III. We also observed a significant decreasing trend in the mean LN count (p<0.05) and blood vessel invasion (p=0.023) from younger to older age groups.
More aggressive disease for younger age groups, earlier peak incidence age and high rate of advanced BC at the time of diagnosis among Iranian women, were the main findings of this study.
乳腺癌（BC）是全球女性中最常见的癌症，也是过去几十年来伊朗女性中最常见的恶性肿瘤。发展中国家乳腺癌呈上升趋势且死亡率高，因此有必要开展针对亚洲国家乳腺癌特征的研究。本研究聚焦于伊朗女性乳腺癌的临床和组织病理学特征。
这项回顾性研究纳入了714例经组织病理学证实患有乳腺癌且接受原发性肿瘤切除及腋窝清扫术的伊朗患者。收集了1994年至2009年四个时间阶段中十年年龄组（≤40岁、41 - 50岁、51 - 60岁、61 - 70岁和≤71岁）的人口统计学、临床和组织病理学数据并进行研究。
患者的平均年龄为49.4±13.1岁。大多数病例（33.2%）在41 - 50岁年龄组。原发性肿瘤的平均大小为3.94±2.47厘米，87.1%的病例为浸润性导管癌。改良根治性乳房切除术是最常用的手术方法（48.8%）。约57.1%的肿瘤处于pT2期，在此期间肿瘤大小显著减小（p<0.05）。最常见的乳腺癌分期为Ⅲa期（27%）。较低的乳腺癌分期（0期和1期）占确诊肿瘤的13.9%。与年龄较大的组相比，我们这组年龄≤40岁的患者肿瘤更大（平均4.73≤3.02厘米）（p = 0.003）。较低分期（0期和Ⅰ期）在年龄最大的患者中更为常见，而年龄≤40岁的患者中近50%患有Ⅲ期肿瘤。我们还观察到从较年轻到较年长年龄组，平均淋巴结计数（p<0.05）和血管侵犯（p = 0.023）呈显著下降趋势。
本研究的主要发现是，伊朗女性中年龄较小的组疾病侵袭性更强、发病高峰年龄更早且诊断时晚期乳腺癌的比例较高。
