Bucheon and Seoul, Republic of Korea From the Departments of Ophthalmology and Pathology, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine; and the Department of Ophthalmology, Kim's Eye Hospital, Myung-Gok Eye Research Institute, Konyang University College of Medicine.
Plast Reconstr Surg. 2014 Apr;133(4):879-886. doi: 10.1097/PRS.0000000000000050.
The purpose of this study was to report 10 years of experience with unilateral conjunctival mullerectomy in the Asian eyelid.
Medical records of patients with unilateral ptosis who underwent conjunctival mullerectomy performed by a single surgeon from January of 2001 to December of 2011 were reviewed. The following factors were investigated: preoperative marginal reflex distance-1 of the ptotic and contralateral normal eyelids, levator function, and preoperative marginal reflex distance-1 after instillation of 2.5% phenylephrine of the ptotic eye. Main outcome measures were the surgical success rate of conjunctival mullerectomy, comparison of preoperative factors according to surgical results, and the results of univariate and multiple logistic regression analyses to identify the factors associated with undercorrection of conjunctival mullerectomy.
Of a total of 64 eyes (64 patients), 53 eyes (82.8 percent) showed surgical success, two eyes (3.1 percent) showed overcorrection, and nine eyes (14.1 percent) showed undercorrection. The mean preoperative marginal reflex distance-1 difference between both eyes was 2.20 mm in the undercorrection group and 1.40 mm in the surgical success group (p = 0.001). The percentage of patients in whom the phenylephrine test did not raise the lid up to the height of the nonptotic eyelid was 88.9 percent (eight of nine eyes) in the undercorrection group, and 28.3 percent (15 of 53 eyes) and 0 percent (zero of two eyes) in the surgical success and overcorrection groups, respectively (p = 0.001). Multiple logistic regression analysis showed that patients in whom the phenylephrine test did not raise the lid up to the height of the nonptotic eyelid were associated with an increased risk of undercorrection after conjunctival mullerectomy (OR, 10.740; 95 percent confidence interval, 1.098 to 15.431; p = 0.041). We observed 0.18 ± 0.08-mm lid elevation per 1 mm of conjunctival mullerectomy.
Conjunctival mullerectomy can be successfully performed to correct unilateral ptosis in the Asian eyelid in 82.8 percent of patients. Patients with greater degrees of preoperative ptosis and those in whom the phenylephrine test did not raise the lid up to the height of the nonptotic eyelid have a higher possibility of undercorrection.
CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, IV.
本研究旨在报告亚洲人眼睑单侧结膜 Muller 切除术 10 年的经验。
回顾了 2001 年 1 月至 2011 年 12 月期间,由一位外科医生对单侧上睑下垂患者进行结膜 Muller 切除术的病历。研究了以下因素:上睑下垂和对侧正常眼睑的术前边缘反射距离-1(MRD1)、提上睑肌功能和术前滴用 2.5%苯肾上腺素后上睑下垂眼的 MRD1。主要观察指标是结膜 Muller 切除术的手术成功率、根据手术结果比较术前因素以及单变量和多变量逻辑回归分析确定与结膜 Muller 切除术矫正不足相关的因素。
共 64 只眼(64 例)中,53 只眼(82.8%)手术成功,2 只眼(3.1%)过矫,9 只眼(14.1%)矫正不足。在矫正不足组,双眼术前 MRD1 差值的平均值为 2.20mm,在手术成功组为 1.40mm(p=0.001)。在矫正不足组,88.9%(9 只眼)的患者在滴用苯肾上腺素后上睑无法提升至非下垂侧的高度,而手术成功组为 28.3%(53 只眼)和 0%(2 只眼)(p=0.001)。多变量逻辑回归分析显示,在滴用苯肾上腺素后上睑无法提升至非下垂侧的高度的患者,结膜 Muller 切除术后矫正不足的风险增加(OR,10.740;95%置信区间,1.098 至 15.431;p=0.041)。我们观察到每切除 1mm 结膜 Muller 可使上睑抬高 0.18±0.08mm。
在 82.8%的亚洲人眼睑单侧上睑下垂患者中,结膜 Muller 切除术可成功矫正。术前上睑下垂程度较大且苯肾上腺素试验无法使上睑提升至非下垂侧高度的患者,矫正不足的可能性较高。
临床问题/证据水平:治疗性,IV。