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采用瓣膜下技术优化缺血性二尖瓣反流的手术修复。

Subvalvular techniques to optimize surgical repair of ischemic mitral regurgitation.

机构信息

aThoracic Surgery Residency Program, University of Virginia bDepartment of Surgery, University of Virginia, Charlottesville, Virginia, USA.

出版信息

Curr Opin Cardiol. 2014 Mar;29(2):140-4. doi: 10.1097/HCO.0000000000000042.

Abstract

PURPOSE OF REVIEW

Surgical treatment of ischemic mitral regurgitation with reduction annuloplasty is the current standard of practice, yet recurrence rates approaching 30% limit the benefits of repair in this subset of patients. In an effort to improve outcomes, attention has turned to understanding the contribution of leaflet tethering in this disease process. Subvalvular techniques to alleviate leaflet restriction have recently been incorporated into methods of repair.

RECENT FINDINGS

Parameters of left ventricular remodeling have been quantified as risk factors for recurrence of mitral regurgitation following reduction annuloplasty. Papillary muscle relocation restores the physiologic configuration of the subvalvular apparatus, and results in significantly reduced rates of recurrent mitral regurgitation and adverse cardiac events over time. Secondary chordal cutting or reimplantation results in significantly increased leaflet mobility, decreased severity of recurrent mitral regurgitation, and improved reverse remodeling without adverse effect on left ventricular function.

SUMMARY

A superior repair with decreased recurrence of mitral regurgitation and enhanced reversal of left ventricular remodeling is possible when subvalvular techniques are combined with traditional ring annuloplasty. Further understanding of preoperative parameters that predict disease recurrence and inclusion of concomitant subvalvular techniques in this subset of patients will be the next major advance in this field.

摘要

目的综述

对于缺血性二尖瓣反流患者,采用修复术进行二尖瓣环成形术是目前的标准治疗方法,但接近 30%的复发率限制了此类患者的修复效果。为了改善治疗效果,人们开始关注瓣叶牵张在这一疾病过程中的作用。最近,已经将减轻瓣叶限制的瓣下技术纳入修复方法中。

最新发现

左心室重构的参数已被量化为二尖瓣环成形术后二尖瓣反流复发的危险因素。乳头肌移位恢复了瓣下装置的生理结构,随着时间的推移,显著降低了二尖瓣反流复发和不良心脏事件的发生率。继发性腱索切断或再植入可显著增加瓣叶活动度,降低二尖瓣反流的严重程度,并改善心室重构的逆转,而不会对左心室功能产生不良影响。

总结

当瓣下技术与传统的环成形术相结合时,可实现更好的修复效果,降低二尖瓣反流的复发率,并增强左心室重构的逆转。进一步了解术前参数,预测疾病复发,并将这些瓣下技术纳入此类患者,将是该领域的下一个重大进展。

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本文引用的文献

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The papillary muscle sling for ischemic mitral regurgitation.用于缺血性二尖瓣反流的乳头肌悬带
J Thorac Cardiovasc Surg. 2010 Feb;139(2):418-23. doi: 10.1016/j.jtcvs.2009.08.007.

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