结节型肺腺癌肿瘤间质特征与动态增强MDCT表现的相关性
Correlations between tumor stroma characters and dynamic enhanced MDCT findings in nodular pulmonary adenocarcinoma.
作者信息
Wang Yong, Wang Jin-an, Liang Kun-ru, Liang Ming-zhu, Liu Xue-guo
机构信息
From the *Department of Radiology, Zhongshan Hospital of Xiamen University, Xiamen, Fujian Province; and †Department of Radiology, The 5th Affiliated Hospital of Sun Yat-Sen University, Zhuhai, Guang Dong Province, China.
出版信息
J Comput Assist Tomogr. 2014 Jan-Feb;38(1):82-8. doi: 10.1097/RCT.0b013e3182a38ad5.
OBJECTIVE
This study aimed to evaluate correlations between tumor stroma characters and dynamic contrast-enhanced computed tomographic (CT) findings in nodular pulmonary adenocarcinoma.
METHODS
Thirty-three patients with nodular pulmonary adenocarcinoma underwent dynamic contrast-enhancement CT scan before surgery. CT findings include wash-in, wash-out, and distribution of enhancement. The proportion of invasive and noninvasive stroma in tumor was calculated.
RESULTS
Invasive and noninvasive stroma proportion in tumor was correlated positively with wash-in and wash-out enhancement, respectively.
CONCLUSIONS
Tumor stroma proliferation may explain the pathologic basis of CT dynamic enhancement and be a useful prognostic factor of pulmonary adenocarcinoma.
目的
本研究旨在评估结节状肺腺癌的肿瘤基质特征与动态对比增强计算机断层扫描（CT）结果之间的相关性。
方法
33例结节状肺腺癌患者在手术前接受了动态对比增强CT扫描。CT表现包括强化程度、强化消退情况及强化分布。计算肿瘤中浸润性和非浸润性基质的比例。
结果
肿瘤中浸润性和非浸润性基质比例分别与强化程度和强化消退情况呈正相关。
结论
肿瘤基质增殖可能解释CT动态增强的病理基础，并且是肺腺癌有用的预后因素。
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