Yamashita K, Matsunobe S, Takahashi R, Tsuda T, Matsumoto K, Miki H, Oyanagi H, Konishi J
Department of Radiology, Shiga Health Insurance Hospital, Otsu, Japan.
Radiology. 1995 Aug;196(2):401-8. doi: 10.1148/radiology.196.2.7617852.
To correlate incremental dynamic computed tomographic (CT) and pathologic findings in peripheral lung cancer.
Lung lesions smaller than 3 cm in diameter were evaluated in 18 patients. CT values of the inner area of the nodule at plain CT and at 30 seconds, 2 minutes, and 5 minutes after administration of nonionic contrast material were calculated with incremental dynamic CT. Maximum attenuation was compared with pathologic type of lung carcinoma and with number of vessels and distribution of elastic fibers in the pathologic specimen.
Enhancement of all lesions was statistically significant (P < .0001). Maximum attenuation of lung carcinomas correlated positively with number of small vessels (diameter, 0.02-0.10 mm) (r = .77). Distribution of elastic fibers in the tumoral interstitium correlated with maximum attenuation (P = .04 between grades 1 and 3) and with number of small vessels (P = .01 between grades 1-3; P = .008 between grades 1 and 3).
Enhancement characteristics of lung carcinomas reflect the number of small tumoral vessels and the distribution of elastic fibers in the tumoral interstitium.
探讨周围型肺癌的动态增强CT表现与病理结果之间的相关性。
对18例直径小于3cm的肺部病变患者进行研究。通过动态增强CT测量平扫及注射非离子型对比剂后30秒、2分钟、5分钟时结节内部区域的CT值。将最大强化值与肺癌的病理类型、病理标本中的血管数量及弹性纤维分布进行比较。
所有病变的强化均具有统计学意义（P < .0001）。肺癌的最大强化值与小血管数量（直径0.02 - 0.10mm）呈正相关（r = .77）。肿瘤间质中弹性纤维的分布与最大强化值相关（1级与3级之间P = .04），与小血管数量也相关（1 - 3级之间P = .01；1级与3级之间P = .008）。
肺癌的强化特征反映了肿瘤内小血管数量及肿瘤间质中弹性纤维的分布。
