Department of Periodontics, Government Dental College and Research Institute, Bangalore, 560002, Karnataka, India,
Inflamm Res. 2014 Apr;63(4):317-23. doi: 10.1007/s00011-013-0703-3. Epub 2013 Dec 31.
The aim of the present study was to evaluate the levels and correlation of human S100A12 and high-sensitivity C-reactive protein (hs-CRP) in gingival crevicular fluid (GCF) and serum in chronic periodontitis (CP) subjects with and without type 2 diabetes mellitus (DM).
A total of 44 subjects were divided into three groups: group 1 had 10 periodontally healthy subjects, group 2 consisted of 17 CP subjects and group 3 had 17 type 2 DM subjects with CP. GCF and serum levels of human S100A12 and hs-CRP were quantified using enzyme-linked immunosorbent assay and immunoturbidimetric analysis, respectively. The clinical outcomes evaluated were gingival index, probing depth and clinical attachment level and the correlations of the two inflammatory mediators with clinical parameters were evaluated.
Both human S100A12 and hs-CRP levels increased from group 1 to group 2 to group 3. The GCF and serum values of both these inflammatory mediators correlated positively with each other and with the periodontal parameters evaluated (p < 0.05).
Human S100A12 and hs-CRP can be considered as possible GCF and serum markers of inflammatory activity in CP and DM.
本研究旨在评估慢性牙周炎（CP）伴或不伴 2 型糖尿病（DM）患者龈沟液（GCF）和血清中人 S100A12 和高敏 C 反应蛋白（hs-CRP）的水平及其相关性。
共 44 名受试者分为三组：第 1 组有 10 名牙周健康受试者，第 2 组有 17 名 CP 受试者，第 3 组有 17 名 CP 伴 2 型 DM 受试者。使用酶联免疫吸附试验和免疫比浊法分别定量测定人 S100A12 和 hs-CRP 的 GCF 和血清水平。评估的临床结果包括牙龈指数、探诊深度和临床附着水平，并评估这两种炎症介质与临床参数的相关性。
人 S100A12 和 hs-CRP 水平均从第 1 组增加到第 2 组，再增加到第 3 组。这两种炎症介质的 GCF 和血清值彼此之间以及与评估的牙周参数均呈正相关（p<0.05）。
人 S100A12 和 hs-CRP 可被视为 CP 和 DM 中 GCF 和血清炎症活动的可能标志物。
