Department of Tuberculosis, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan Province, P.R. China.
Eur Rev Med Pharmacol Sci. 2013 Dec;17(24):3329-33.
To explore the diagnostic value of serum procalcitonin (PCT), interleukin-10 (IL-10), C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) in community acquired pneumonia (CAP) and tuberculosis (PTB).
113 CAP cases patients and 78 PTB cases were enrolled from May 2011 to March 2012. Routine blood test, serum PCT, CRP, IL-10 and ESR of patients within 24 hours were analyzed retrospectively.
The serum concentrations of PCT, IL-10, CRP and ESR in CAP patients with CAP were 0.35±0.017 mg/mL, 0.095±0.004 mg/L, 59.80±5.12 mg/L and 35.00±4.81 mm/1h, respectively, significantly higher than patients with PTB (p < 0.01); According to the result of ROC curve analysis in CAP and PTB, the PTC area under ROC curve is 0.715 (95% CI 0.647-0.782), the sensitivity and specific degree of serum PTC were significant better than CRP and IL10 (p < 0.05). In tuberculosis sputum culture, the serum concentrations of IL-10 and ESR in TB positive group were 0.045±0.013 mg/L and 62.50±8.69 mm/1h, significantly higher than that of TB negative group (p < 0.05); whereas, the concentrations of serum PCT and CRP in TB positive and negative groups had no significant difference (p > 0.05).
The levels of serum PCT, IL-10, CRP and ESR in CAP patients are higher than that in PTB patients. Therefore, the serum PCT, IL10, CRP and ESR level is benefit to distinguish between CAP and PTB. This could provide a comprehensible evidence for both diagnosis and prognosis.
探讨血清降钙素原（PCT）、白细胞介素-10（IL-10）、C 反应蛋白（CRP）和红细胞沉降率（ESR）在社区获得性肺炎（CAP）和肺结核（PTB）中的诊断价值。
回顾性分析 2011 年 5 月至 2012 年 3 月收治的 113 例 CAP 患者和 78 例 PTB 患者的常规血液检查、血清 PCT、CRP、IL-10 和 ESR 结果。
CAP 患者血清 PCT、IL-10、CRP 和 ESR 浓度分别为 0.35±0.017mg/mL、0.095±0.004mg/L、59.80±5.12mg/L 和 35.00±4.81mm/1h，均显著高于 PTB 患者（p<0.01）；根据 CAP 和 PTB 的 ROC 曲线分析结果，PTC 的 ROC 曲线下面积为 0.715（95%CI 0.647-0.782），血清 PTC 的灵敏度和特异度均显著优于 CRP 和 IL10（p<0.05）。在肺结核痰培养中，TB 阳性组的血清 IL-10 和 ESR 浓度分别为 0.045±0.013mg/L 和 62.50±8.69mm/1h，显著高于 TB 阴性组（p<0.05）；而 TB 阳性和阴性组的血清 PCT 和 CRP 浓度无显著差异（p>0.05）。
CAP 患者的血清 PCT、IL-10、CRP 和 ESR 水平高于 PTB 患者。因此，血清 PCT、IL10、CRP 和 ESR 水平有助于区分 CAP 和 PTB。这可为诊断和预后提供明确的证据。
