寄生虫感染与儿童结核病：病例对照研究。
Parasite infection and tuberculosis disease among children: a case-control study.
机构信息
Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts; Partners In Health/Socios En Salud Sucursal Peru, Lima, Peru; Instituto Nacional de Salud del Niño, Lima, Peru; Dartmouth Center for Health Care Delivery Science, Dartmouth College, Hanover, New Hampshire; Division of Global Health Equity, Brigham and Women's Hospital, Boston, Massachusetts.
出版信息
Am J Trop Med Hyg. 2014 Feb;90(2):279-82. doi: 10.4269/ajtmh.13-0425. Epub 2013 Dec 30.
We conducted a case-control study to examine associations between parasite infection, including protozoa infection, and tuberculosis (TB) in children in Lima, Peru. We enrolled 189 matched-pairs. In multivariable conditional logistic regression analyses, Blastocystis hominis infection (rate ratio = 0.30, 95% confidence interval = 0.14-0.64, P = 0.002) was strongly associated with a lower risk of TB. We observed a statistically significant inverse linear dose-response relationship between Blastocystis hominis infection and TB. These findings should be confirmed in future prospective studies.
我们在秘鲁利马进行了一项病例对照研究，以探讨寄生虫感染（包括原生动物感染）与儿童结核病（TB）之间的关联。我们纳入了 189 对匹配的病例对照。在多变量条件逻辑回归分析中，Blastocystis hominis 感染（率比=0.30，95%置信区间=0.14-0.64，P=0.002）与结核病风险降低呈强烈相关。我们观察到 Blastocystis hominis 感染与结核病之间存在统计学上显著的负线性剂量反应关系。这些发现应在未来的前瞻性研究中得到证实。
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