Pektasides D, Rustin G J, Newlands E S, Begent R H, Bagshawe K D
Br J Obstet Gynaecol. 1987 May;94(5):477-9. doi: 10.1111/j.1471-0528.1987.tb03129.x.
Gonadal function was assessed in 17 women who successfully completed chemotherapy with the POMB/ACE regimen (cisplatin, vincristine [Oncovin], methotrexate, bleomycin/actinomycin D, cyclophosphamide, etoposide) for ovarian germ cell tumours, and had a remaining ovary and uterus. A 20-year-old girl has not yet recovered menstruation 5 months off chemotherapy. All the remaining women whose mean age at start of chemotherapy was 21 (9-38) are now menstruating with a median time of recovery of 41/2 months after completion of chemotherapy. Five women have so far conceived after chemotherapy resulting in three full term normal deliveries of healthy infants, one termination of pregnancy, two miscarriages and one continuing pregnancy. Gonadal function does not appear to be permanently impaired in the majority of patients receiving POMB/ACE chemotherapy for ovarian germ cell tumours.
对17名成功完成POMB/ACE方案（顺铂、长春新碱[安可平]、甲氨蝶呤、博来霉素/放线菌素D、环磷酰胺、依托泊苷）化疗的卵巢生殖细胞肿瘤女性患者的性腺功能进行了评估，这些患者保留了卵巢和子宫。一名20岁女孩化疗结束5个月后仍未恢复月经。其余所有女性化疗开始时的平均年龄为21岁（9 - 38岁），目前均已恢复月经，化疗结束后恢复月经的中位时间为4个半月。到目前为止，有5名女性在化疗后怀孕，其中3例足月顺产健康婴儿，1例人工流产，2例流产，1例仍在妊娠。对于大多数接受POMB/ACE化疗的卵巢生殖细胞肿瘤患者，性腺功能似乎不会受到永久性损害。
