Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China ; The Key Laboratory of Remodeling-Related Cardiovascular Diseases, Capital Medical University, Ministry of Education, Beijing 100029, China ; Beijing Institute of Heart, Lung and Blood Vessel Disease, Beijing 100029, China.
Oxid Med Cell Longev. 2013;2013:943416. doi: 10.1155/2013/943416. Epub 2013 Nov 28.
The elderly are the major population receiving the implantation of a permanent pacemaker (PPM). Infection is a devastating complication. The present study is to verify the relationship between age and PPM implantation infection.
All patients (162 adult and 292 elder patients) received the implantation of PPM. Subcutaneous tissue samples solution was collected in three time points, the first sample was got at skin incision, and the second sample was got when the PPM had been implanted. And the third sample was got after 0.9% NaCl quick rinse. And the tissue solutions were cultured. If culture results are positive, it is considered as evidence of the presence of bacteria in pocket in operation of PPM implantation.
The data demonstrated that compared with that in the adult patients, subcutaneous bacterial survival rate was higher significantly in the elderly. Staphylococcus epidermidis is the major bacterial strain. The rinse decreased subcutaneous bacterial survival rates in the adult group.
With the age increasing, PPM implantation might be easier to result in infection. Simple rinse can prevent implantation infection significantly. However, age alleviated the protective effects of rinse. Therefore, we should pay more attention to post implantation infection in the elderly.
老年人是接受永久性心脏起搏器（PPM）植入的主要人群。感染是一种破坏性的并发症。本研究旨在验证年龄与 PPM 植入感染之间的关系。
所有患者（162 名成年患者和 292 名老年患者）均接受了 PPM 植入。在三个时间点采集皮下组织样本溶液，第一次在皮肤切口时采集，第二次在 PPM 植入时采集，第三次在 0.9%NaCl 快速冲洗后采集。并对组织溶液进行培养。如果培养结果为阳性，则认为在 PPM 植入手术的口袋中存在细菌。
数据表明，与成年患者相比，老年患者的皮下细菌存活率明显更高。表皮葡萄球菌是主要的细菌菌株。冲洗可降低成年组皮下细菌存活率。
随着年龄的增长，PPM 植入可能更容易导致感染。简单冲洗可显著预防植入感染。然而，年龄减轻了冲洗的保护作用。因此，我们应该更加关注老年人的植入后感染。
