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一名患有冯·希佩尔-林道病的患者,其幕上脑膜血管母细胞瘤酷似血管母细胞性脑膜瘤。

Meningeal supratentorial hemangioblastoma in a patient with von hippel-lindau disease mimicking angioblastic menigioma.

作者信息

Kim Hoon, Park Ik-Seong, Jo Kwang Wook

机构信息

Department of Neurosurgery, The Catholic University of Korea College of Medicine, Bucheon St. Mary's Hospital, Bucheon, Korea.

出版信息

J Korean Neurosurg Soc. 2013 Nov;54(5):415-9. doi: 10.3340/jkns.2013.54.5.415. Epub 2013 Nov 30.

Abstract

Hemangioblastomas are sporadic tumors found in the cerebellum or spinal cord. Supratentorial hemangioblastomas are rare, and those with meningeal involvement are extremely rare and have been reported in only approximately 130 patients. Here, we report the case of a 51-year-old female patient with supratentorial meningeal hemangioblastoma detected 5 years after surgical resection of an infratentorial hemangioblastoma associated with von Hippel-Lindau disease. Patients with von Hippel-Lindau syndrome are at risk for developing multiple hemangioblastomas, with new tumor formation and growth and possible meningeal infiltration. Regular lifelong follow-up in at-risk patients is recommended and should include the differential diagnosis of dural-based tumors such as angioblastic meningioma and metastatic renal cell carcinoma.

摘要

血管母细胞瘤是散发性肿瘤,见于小脑或脊髓。幕上血管母细胞瘤罕见,累及脑膜的幕上血管母细胞瘤极为罕见,仅有约130例患者的相关报道。在此,我们报告一例51岁女性患者,该患者在手术切除与冯·希佩尔-林道病相关的幕下血管母细胞瘤5年后,被检测出患有幕上脑膜血管母细胞瘤。冯·希佩尔-林道综合征患者有发生多发性血管母细胞瘤的风险,可出现新的肿瘤形成和生长以及可能的脑膜浸润。建议对高危患者进行终身定期随访,随访应包括对诸如血管母细胞性脑膜瘤和转移性肾细胞癌等硬脑膜源性肿瘤的鉴别诊断。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b36c/3873355/442ab9bb7e4f/jkns-54-415-g001.jpg

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