Cozette P, Laxenaire M C, Borgo J
Ann Anesthesiol Fr. 1977;18(11):911-5.
A review of the recent literature indicates that fat overload during the infusion of lipid emulsions remains rare, at least clinically. Nevertheless, two pictures may be seen, the physiopathology of which is discussed:--overload syndrome, with an association essentially of general and digestive signs, related to the accumulation of lipids in a certain number of parenchymatous tissues;--fat embolism. Problem may be seen at any time after administration of the solution is begun. Youth seems to predominate amongst the favourising factors. Prevention is possible if rules of caution concerning dose and the rate of administration are respected, combined with biological surveillance involving at laboratory studies at least once a week.
近期文献综述表明,至少在临床上,输注脂质乳剂期间脂肪超载情况仍然罕见。然而,可能会出现两种情况,现将其病理生理学讨论如下:——超载综合征,主要伴有全身和消化系统症状,与脂质在一定数量实质组织中的蓄积有关;——脂肪栓塞。在开始输注溶液后的任何时间都可能出现问题。年轻人似乎是主要的易感因素。如果遵守关于剂量和给药速度的谨慎规则,并结合至少每周进行一次实验室研究的生物学监测,预防是可行的。