Wattel F, Durocher A, Crasquin O, Dewailly P, Romon M
Ann Anesthesiol Fr. 1977;18(11):916-20.
Lipid emulsions based upon soya triglycerides and widely used in parenteral nutrition. Haematological surveillance of the patients, and in particular the study of coagulation, shows slight changes in platelet adhesiveness and a transient hypercoagulability state proportional to the concentration of the lipid emulsion. Nevertheless, these findings must be interpreted with the greatest caution, inasmuch as the laboratory tests involved are technically delicate. The results obtained may be contradictory according to the protocol used. Finally, in patients receiving intensive therapy, there are multiple factors (stress, prolonge;d bedrest, hypercatabolism) which may alter coagulation quite independently of the prescription of lipids.
基于大豆甘油三酯的脂质乳剂广泛用于肠外营养。对患者的血液学监测,尤其是凝血研究表明,血小板黏附性有轻微变化,且存在与脂质乳剂浓度成比例的短暂高凝状态。然而,由于所涉及的实验室检测技术要求高,这些结果必须极其谨慎地解读。根据所使用的方案,获得的结果可能相互矛盾。最后,在接受强化治疗的患者中,有多种因素(应激、长期卧床、高分解代谢)可能会独立于脂质处方而改变凝血功能。