Sopotsinskaia E B, Lisniak I A, Balitskiĭ K P
Eksp Onkol. 1987;9(2):55-7.
Preparations extracted from the vitreous body were studied for their effect on the activity of angiogenesis and metastatic spreading. A semipurified extract and a protein preparation with molecular weight 12,000 exerted an inhibitory effect on metastasis growth of Lewis carcinoma after removal of the primary tumour. Application of these preparations has also led to an inhibition of the capillary network growth which developed subcutaneously in the site of the organic glass plate implanting, which was considered as an inhibition of the angiogenesis activity. Such an effect was not observed with the use of hyaluronate, extracted from the vitreous body.
研究了从玻璃体中提取的制剂对血管生成和转移扩散活性的影响。一种半纯化提取物和一种分子量为12,000的蛋白质制剂在切除原发性肿瘤后对Lewis癌的转移生长具有抑制作用。应用这些制剂还导致在有机玻璃板植入部位皮下形成的毛细血管网络生长受到抑制，这被认为是血管生成活性受到抑制。而使用从玻璃体中提取的透明质酸盐则未观察到这种效果。
