Baier W K, Doose H
Electroencephalogr Clin Neurophysiol. 1987 Jun;66(6):483-8. doi: 10.1016/0013-4694(87)90094-0.
The present study is based on the data of a more extensive investigation of the genetics of spike-wave epilepsies of childhood with minor seizures (Doose and Baier 1987). It evaluated EEG findings in 271 siblings of patients by means of log-linear methods. The risk of siblings to manifest spikes and waves during rest or hyperventilation is distinctly increased if they are positive for 4-7 Hz rhythms, and to a lesser degree, if they are photosensitive. Moreover, siblings of female patients seem to be at a higher risk of manifest spikes and waves than siblings of males. 4-7 Hz rhythms of the EEG background activity and photosensitivity are mutually independent symptoms of an increased liability to manifest spikes and waves. These findings are discussed in the context of a 'multifactorial' background of spikes and waves.
本研究基于对伴有轻微发作的儿童棘波癫痫遗传学更广泛调查的数据（杜斯和拜尔，1987年）。它采用对数线性方法评估了271名患者兄弟姐妹的脑电图结果。如果兄弟姐妹的脑电图背景活动出现4 - 7Hz节律，其在静息或过度换气时出现棘波和慢波的风险会显著增加；若有光敏性，风险增加程度较小。此外，女性患者的兄弟姐妹出现棘波和慢波的风险似乎高于男性患者的兄弟姐妹。脑电图背景活动的4 - 7Hz节律和光敏性是出现棘波和慢波易感性增加的相互独立症状。这些发现是在棘波和慢波的“多因素”背景下进行讨论的。
