Yamamoto H, Araki K, Bitoh S, Takata M, Takahashi S, Fujimoto S
Eur J Immunol. 1987 May;17(5):719-22. doi: 10.1002/eji.1830170522.
MOPC 104E idiotype-specific cytotoxic T lymphocyte (CTL) clones were established. The clone KA1.02 specifically killed MOPC 104E cells and inhibited anti-dextran antibody production in an idiotype-specific manner. Both cytotoxicity and antibody inhibition were restricted to the cross-reactive idiotype and class I histocompatibility antigen. The data presented here provide definitive evidence that the self idiotype is the immunogenic determinant recognized by T lymphocytes in association with the major histocompatibility complex product. A regulatory role of CTL in antibody response is proposed.
建立了MOPC 104E独特型特异性细胞毒性T淋巴细胞（CTL）克隆。克隆KA1.02能特异性杀伤MOPC 104E细胞，并以独特型特异性方式抑制抗葡聚糖抗体的产生。细胞毒性和抗体抑制均局限于交叉反应独特型和I类组织相容性抗原。本文提供的确凿证据表明，自身独特型是与主要组织相容性复合体产物相关联的、被T淋巴细胞识别的免疫原性决定簇。提出了CTL在抗体应答中的调节作用。
