从癌症基因组图谱中描述 DNA 甲基化改变。
Characterizing DNA methylation alterations from The Cancer Genome Atlas.
出版信息
J Clin Invest. 2014 Jan;124(1):17-23. doi: 10.1172/JCI69740. Epub 2014 Jan 2.
Abstract
The Cancer Genome Atlas (TCGA) Research Network is an ambitious multi-institutional consortium effort aimed at characterizing sequence, copy number, gene (mRNA) expression, microRNA expression, and DNA methylation alterations in 30 cancer types. TCGA data have become an extraordinary resource for basic, translational, and clinical researchers and have the potential to shape cancer diagnostic and treatment strategies. DNA methylation changes are integral to all aspects of cancer genomics and have been shown to have important associations with gene expression, sequence, and copy number changes. This Review highlights the knowledge gained from DNA methylation alterations in human cancers from TCGA.
摘要
癌症基因组图谱（TCGA）研究网络是一项雄心勃勃的多机构联盟努力，旨在描述 30 种癌症类型中的序列、拷贝数、基因（mRNA）表达、microRNA 表达和 DNA 甲基化改变。TCGA 数据已成为基础、转化和临床研究人员的宝贵资源，并有潜力改变癌症诊断和治疗策略。DNA 甲基化改变是癌症基因组学各个方面的重要组成部分，并且已经显示出与基因表达、序列和拷贝数改变的重要关联。这篇综述强调了从 TCGA 人类癌症中的 DNA 甲基化改变中获得的知识。
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