癌症基因组与表观基因组的相互作用。
Interplay between the cancer genome and epigenome.
机构信息
USC Epigenome Center, University of Southern California, Room G511B, 1450 Biggy Street, Los Angeles, CA 90089-9061, USA.
出版信息
Cell. 2013 Mar 28;153(1):38-55. doi: 10.1016/j.cell.2013.03.008.
Abstract
Cancer arises as a consequence of cumulative disruptions to cellular growth control with Darwinian selection for those heritable changes that provide the greatest clonal advantage. These traits can be acquired and stably maintained by either genetic or epigenetic means. Here, we explore the ways in which alterations in the genome and epigenome influence each other and cooperate to promote oncogenic transformation. Disruption of epigenomic control is pervasive in malignancy and can be classified as an enabling characteristic of cancer cells, akin to genome instability and mutation.
摘要
癌症是细胞生长控制的累积性破坏的结果，达尔文选择了那些能提供最大克隆优势的可遗传变化。这些特征可以通过遗传或表观遗传手段获得并稳定维持。在这里，我们探讨了基因组和表观基因组的改变如何相互影响并合作促进致癌转化。表观基因组控制的破坏在恶性肿瘤中普遍存在，可被归类为癌细胞的一种赋形特征，类似于基因组不稳定性和突变。
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