熔炉守护者：线粒体、TRAP1、活性氧与干细胞维持

Guardian of the furnace: mitochondria, TRAP1, ROS and stem cell maintenance.

作者信息

Kadye Rose, Kramer Adam H, Joos-Vandewalle Julia, Parsons Michelle, Njengele Zikhona, Hoppe Heinrich, Prinsloo Earl

机构信息

Biomedical Biotechnology Research Unit, Department of Biochemistry, Microbiology and Biotechnology, Rhodes University, Grahamstown, South Africa.

出版信息

IUBMB Life. 2014 Jan;66(1):42-5. doi: 10.1002/iub.1234. Epub 2013 Dec 30.

DOI:10.1002/iub.1234

PMID:24382805

Abstract

Mitochondria are key to eukaryotic cell survival and their activity is linked to generation of reactive oxygen species (ROS) which in turn acts as both an intracellular signal and an effective executioner of cells with regards to cellular senescence. The mitochondrial molecular chaperone tumor necrosis factor receptor associated protein 1 (TRAP1) is often termed the cytoprotective chaperone for its role in cancer cell survival and protection from apoptosis. Here, we hypothesize that TRAP1 serves to modulate mitochondrial activity in stem cell maintenance, survival and differentiation.

摘要

线粒体是真核细胞存活的关键，其活性与活性氧（ROS）的产生相关，而活性氧反过来既作为细胞内信号，又在细胞衰老方面作为细胞的有效执行者。线粒体分子伴侣肿瘤坏死因子受体相关蛋白1（TRAP1）因其在癌细胞存活和抗凋亡中的作用，常被称为细胞保护伴侣。在此，我们假设TRAP1在干细胞维持、存活和分化中发挥调节线粒体活性的作用。