Department of Chemistry, Faculty of Science, University of Malaya, 50603 Lembah Pantai, Kuala Lumpur, Malaysia; Institute for Advanced Chemistry of Catalonia, Consejo Superior de Investigaciones Científicas (IQAC-CSIC), CIBER en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), 08034 Barcelona, Catalunya, Spain.
Institute for Advanced Chemistry of Catalonia, Consejo Superior de Investigaciones Científicas (IQAC-CSIC), CIBER en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), 08034 Barcelona, Catalunya, Spain.
Colloids Surf B Biointerfaces. 2014 Mar 1;115:267-74. doi: 10.1016/j.colsurfb.2013.12.013. Epub 2013 Dec 15.
The effect of incorporating new nonionic glycolipid surfactants on the properties of a model water/nonionic surfactant/oil nano-emulsion system was investigated using branched-chain alkyl glycosides: 2-hexyldecyl-β(/α)-D-glucoside (2-HDG) and 2-hexyldecyl-β(/α)-D-maltoside (2-HDM), whose structures are closely related to glycero-glycolipids. Both 2-HDG and 2-HDM have an identical hydrophobic chain (C16), but the former consists a monosaccharide glucose head group, in contrast to the latter which has a disaccharide maltose unit. Consequently, their hydrophilic-lipophilic balance (HLB) is different. The results obtained have shown that these branched-chain alkyl glycosides affect differently the stability of the nano-emulsions. Compared to the model nano-emulsion, the presence of 2-HDG reduces the oil droplet size, whereas 2-HDM modify the properties of the model nano-emulsion system in terms of its droplet size and storage time stability at high temperature. These nano-emulsions have been proven capable of encapsulating ketoprofen, showing a fast release of almost 100% in 24h. Thus, both synthetically prepared branched-chain alkyl glycosides with mono- and disaccharide sugar head groups are suitable as nano-emulsion stabilizing agents and as drug delivery systems in the future.
2-己基十二烷基-β( /α)-D-吡喃葡萄糖苷(2-HDG)和 2-己基十二烷基-β( /α)-D-麦芽糖苷(2-HDM)研究了新型非离子糖脂表面活性剂对水/非离子表面活性剂/油纳米乳液体系性能的影响，其结构与甘油糖脂密切相关。2-HDG 和 2-HDM 均具有相同的疏水链(C16)，但前者由单糖葡萄糖头基组成，而后者则具有二糖麦芽糖单元。因此，它们的亲水亲油平衡值(HLB)不同。所得结果表明，这些支链烷基糖苷对纳米乳液的稳定性有不同的影响。与模型纳米乳液相比，2-HDG 的存在会降低油滴粒径，而 2-HDM 则会改变模型纳米乳液体系的性质，包括粒径和高温下的储存时间稳定性。这些纳米乳液已被证明能够包封酮洛芬，在 24 小时内快速释放近 100%。因此，具有单糖和二糖糖基的两种合成支链烷基糖苷都适合作为纳米乳液稳定剂和未来的药物传递系统。
