Mullen Sarah J, Yücel Yeni H, Cusimano Michael, Schweizer Tom A, Oentoro Anton, Gupta Neeru
Can J Neurol Sci. 2014 Jan;41(1):58-65. doi: 10.1017/s0317167100016279.
To investigate whether repeat saccadic reaction time (SRT) measurements using a portable saccadometer is useful to monitor patients with mild traumatic brain injury (mTBI).
Seven patients with newly-diagnosed mTBI and five agematched controls were prospectively recruited from an emergency Department. Saccadic eye movements, symptom self-reporting and neuropsychological tests were performed within one week of injury and again at follow-up three weeks post-injury. Control patients underwent saccade recordings at similar intervals.
Median saccade reaction times were significantly prolonged within one week post-injury in mTBI compared to controls. At follow-up assessment there was no significant between-groups difference. Changes in median SRT between the two assessments were not statistically significant. Four of the seven mTBI patients showed significantly increased SRT at follow-up; three of the mTBI patients and all controls showed no significant change. Among the three mTBI patients with persistent decreased SRT, two experienced loss of consciousness and reported the greatest symptoms, while the third was the only subject with significant decrease in neuropsychological testing scores at both assessments.
In three of seven mTBI patients, saccadic eye movements remained delayed within three weeks post-injury. These three patients also showed persistent symptoms or no improvement on neuropsychological testing. This pilot study using a portable saccadometer suggests that comparing SRT from three weeks post-injury to that within one week of injury may be useful for early detection of a subpopulation at risk of persistent disability from mTBI. This finding suggests that further investigation in a large study population is warranted.
Les saccades oculaires dans le traumatisme cérébral léger : une étude pilote.
研究使用便携式眼跳计重复测量眼跳反应时间（SRT）是否有助于监测轻度创伤性脑损伤（mTBI）患者。
从急诊科前瞻性招募了7例新诊断的mTBI患者和5例年龄匹配的对照者。在受伤后1周内以及受伤后3周的随访时进行眼跳运动、症状自我报告和神经心理学测试。对照患者在相似的时间间隔进行眼跳记录。
与对照组相比，mTBI患者受伤后1周内眼跳反应时间的中位数显著延长。在随访评估时，组间无显著差异。两次评估之间中位数SRT的变化无统计学意义。7例mTBI患者中有4例在随访时SRT显著增加；3例mTBI患者和所有对照者均无显著变化。在3例SRT持续降低的mTBI患者中，2例曾有过意识丧失且症状最严重，而第3例是两次评估时神经心理学测试分数均显著降低的唯一受试者。
7例mTBI患者中有3例在受伤后3周内眼跳运动仍延迟。这3例患者在神经心理学测试中也表现出持续的症状或无改善。这项使用便携式眼跳计的初步研究表明，比较受伤后3周与受伤后1周内的SRT可能有助于早期发现有mTBI导致持续性残疾风险的亚组人群。这一发现表明有必要在大量研究人群中进行进一步研究。
轻度创伤性脑损伤中的眼跳：一项初步研究。
