Department of Pediatrics, University of Virginia Health System, Charlottesville, VA, USA Division of Nephrology, University of Virginia Health System, Charlottesville, VA, USA.
Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Nephrol Dial Transplant. 2014 Jul;29(7):1301-11. doi: 10.1093/ndt/gft510. Epub 2014 Jan 2.
Over the last decade, significant progress has been made in the identification and validation of novel biomarkers as well as refinements in the use of serum creatinine as a marker of kidney function. These advances have taken advantage of laboratory investigations, which have identified these novel molecules that serve important biological functions in the pathogenesis of acute kidney injury (AKI). As we advance and validate these markers for clinical studies in AKI, we recognize that they serve not only to improve our understanding of AKI, but they could also serve as potential targets for the treatment of AKI. This review will underscore the biological basis of specific biomarkers that will contribute to the advancement in the treatment and outcomes of AKI.
在过去的十年中，在鉴定和验证新型生物标志物方面取得了重大进展，同时也改进了血清肌酐作为肾功能标志物的使用方法。这些进展利用实验室研究，鉴定了这些新型分子，它们在急性肾损伤 (AKI) 的发病机制中具有重要的生物学功能。随着我们在 AKI 的临床研究中推进和验证这些标志物，我们认识到它们不仅有助于我们加深对 AKI 的理解，而且还可以作为 AKI 治疗的潜在靶点。这篇综述将强调特定生物标志物的生物学基础，这将有助于推进 AKI 的治疗和改善其预后。
