内皮蛋白 C 受体与儿科动脉性脑卒中。
Endothelial protein C receptor and pediatric arterial stroke.
机构信息
Ankara University, School of Medicine, Department of Pediatric Molecular Genetics, Ankara, Turkey.
Ankara University, School of Medicine, Department of Pediatric Neurology, Ankara, Turkey.
出版信息
Turk J Haematol. 2013 Mar;30(1):37-9. doi: 10.4274/tjh.01488. Epub 2013 Mar 5.
OBJECTIVE
The aim of this study was to investigate the endothelial protein C receptor (EPCR) gene A3 haplotype and plasma soluble EPCR (sEPCR) levels in Turkish pediatric arterial stroke patients.
MATERIALS AND METHODS
We analyzed 44 pediatric arterial stroke patients and 75 healthy controls. Following DNA isolation, genotyping of the A3 haplotype was determined via PCR and RFLP. Additionally, fasting sEPCR levels were determined via ELISA.
RESULTS
There wasn't a significant difference in the sEPCR level between the control and patient groups, although the sEPCR level was higher in the patient group. We didn't observe a difference in the distribution of the CC and CG/GG genotypes between the control and patient groups.
CONCLUSION
Further study on sEPCR levels at the onset of pediatric stroke is needed in order to reach a more definitive conclusion.
CONFLICT OF INTEREST
None declared.
目的
本研究旨在探讨土耳其儿科动脉性卒中患者内皮蛋白 C 受体（EPCR）基因 A3 单倍型和血浆可溶性 EPCR（sEPCR）水平。
材料与方法
我们分析了 44 名儿科动脉性卒中患者和 75 名健康对照者。提取 DNA 后，通过 PCR 和 RFLP 确定 A3 单倍型的基因分型。此外，通过 ELISA 测定空腹 sEPCR 水平。
结果
尽管患者组的 sEPCR 水平较高，但对照组和患者组之间的 sEPCR 水平没有显著差异。我们没有观察到对照组和患者组之间 CC 和 CG/GG 基因型的分布有差异。
结论
需要在儿科卒中发病时进一步研究 sEPCR 水平，以得出更明确的结论。
利益冲突
无。
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