Cheng Melody M, Tang Guomei, Kuo Sheng-Han
Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, , New York, United States of America.
Tremor Other Hyperkinet Mov (N Y). 2013 Dec 9;3. doi: 10.7916/D8H993W3. eCollection 2013.
Harmaline-induced tremor in rodents has been extensively used as an animal model for essential tremor (ET). However, there is no visual documentation in the published literature.
We injected mice subcutaneously with either 20 mg/kg of harmaline hydrochloride or saline and then videotaped the responses.
Action and postural tremor in the mouse began 5 minutes after subcutaneous harmaline injection and peaked at approximately 30 minutes. The tremor involved the head, trunk, tail, and four limbs and lasted for approximately 2 hours. The forelimb tremor was postural or action tremor, similar to that observed in ET.
This video segment provides the first visual documentation of the phenomenology of harmaline-induced tremor in a mouse. We also raise several unanswered questions regarding the use of harmaline-induced tremor to model ET.
啮齿动物中，骆驼蓬碱诱发的震颤已被广泛用作特发性震颤（ET）的动物模型。然而，已发表的文献中没有视觉记录。
我们给小鼠皮下注射20mg/kg盐酸骆驼蓬碱或生理盐水，然后拍摄反应过程。
皮下注射骆驼蓬碱后5分钟，小鼠开始出现动作性和姿势性震颤，约30分钟时达到峰值。震颤累及头部、躯干、尾巴和四肢，持续约2小时。前肢震颤为姿势性或动作性震颤，类似于ET中观察到的震颤。
该视频片段首次提供了小鼠中骆驼蓬碱诱发震颤现象学的视觉记录。我们还提出了几个关于使用骆驼蓬碱诱发震颤来模拟ET的未解决问题。
