应用 OCT 壁运动分析对原始几何形状的动脉斑块进行力学分析。
Mechanical analysis of arterial plaques in native geometry with OCT wall motion analysis.
机构信息
Department of Biomedical Engineering, University of California, Irvine, 2121 Engineering Hall, Irvine, CA 92617, USA; The Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, Irvine, USA.
Department of Biomedical Engineering, University of California, Irvine, 2121 Engineering Hall, Irvine, CA 92617, USA; The Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, Irvine, USA; Beckman Laser Institute, University of California, Irvine, CA 92617, USA.
出版信息
J Biomech. 2014 Feb 7;47(3):755-8. doi: 10.1016/j.jbiomech.2013.11.010. Epub 2013 Nov 15.
The mechanical behavior of an atherosclerotic plaque may encode information about the type, composition, and vulnerability to rupture. Human arterial segments with varying plaque burden were analyzed ex vivo with optical coherence tomography (OCT) to determine plaque type and to determine compliance during pulsatile inflation in their native geometry. Calcifications and lipid filled plaques showed markedly different compliance when analyzed with OCT wall motion analysis. There was also a trend towards increased circumferential variation in arterial compliance with increasing plaque burden.
动脉粥样硬化斑块的力学特性可能编码有关斑块类型、组成和易破裂性的信息。通过光学相干断层扫描（OCT）对具有不同斑块负荷的人动脉段进行了离体分析，以确定斑块类型，并在其天然几何形状下进行脉动充气时确定顺应性。用 OCT 壁运动分析分析钙化和富含脂质的斑块时，其顺应性明显不同。随着斑块负荷的增加，动脉顺应性的周向变化也呈增加趋势。
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