Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
JACC Cardiovasc Imaging. 2011 Sep;4(9):1022-39. doi: 10.1016/j.jcmg.2011.03.020.
There is an ever-increasing demand for new imaging methods that can provide additional information about the coronary wall to better characterize and stratify high-risk plaques, and to guide interventional and pharmacologic management of patients with coronary artery disease. While there are a number of imaging modalities that facilitate the assessment of coronary artery pathology, this review paper focuses on intravascular optical imaging modalities that provide information on the microstructural, compositional, biochemical, biomechanical, and molecular features of coronary lesions and stents. The optical imaging modalities discussed include angioscopy, optical coherence tomography, polarization sensitive-optical coherence tomography, laser speckle imaging, near-infrared spectroscopy, time-resolved laser induced fluorescence spectroscopy, Raman spectroscopy, and near-infrared fluorescence molecular imaging. Given the wealth of information that these techniques can provide, optical imaging modalities are poised to play an increasingly significant role in the evaluation of the coronary artery in the future.
人们对新的成像方法的需求日益增长，这些方法可以提供有关冠状动脉壁的额外信息，以更好地对高危斑块进行特征描述和分层，并指导冠心病患者的介入和药物治疗。虽然有许多成像方式可以方便地评估冠状动脉病变，但本篇综述文章专注于血管内光学成像方式，这些方式可以提供有关冠状动脉病变和支架的微观结构、组成、生化、生物力学和分子特征的信息。所讨论的光学成像方式包括血管内镜检查、光学相干断层扫描、偏振敏感光学相干断层扫描、激光散斑成像、近红外光谱、时间分辨激光诱导荧光光谱、拉曼光谱和近红外荧光分子成像。鉴于这些技术可以提供的大量信息，光学成像方式有望在未来的冠状动脉评估中发挥越来越重要的作用。
