Al Hayek Ayman A, Khawaja Nahla M, Khader Yousef S, Jaffal Sahar K, Ajlouni Kamel M
National Center for Diabetes, Endocrinology and Genetics, P.O. Box 13165, Amman 11942, Jordan.
Department of Community Medicine, Public Health and Family Medicine, Faculty of Medicine, Jordan University of Science & Technology, Irbid 22110, Jordan.
J Diabetes Complications. 2014 Mar-Apr;28(2):135-40. doi: 10.1016/j.jdiacomp.2013.11.004. Epub 2013 Nov 14.
Determine the prevalence of hypogonadism among diabetic and non-diabetic men in Jordan.
A cross-sectional study of 1717 men (1089 participants with type 2 diabetes and 628 non-diabetic subjects). Both groups were inquired to answer the Androgen Deficiency for aging male (ADAM) questionnaire. Early morning Total testosterone, prolactin, sex hormone binding globulin, follicle stimulating hormone, leutinizing hormone, HbA1c and fasting blood sugar were measured. Hypogonadism was defined as total testosterone <3 ng/ml and calculated free testosterone <5 ng/dl.
The prevalence of Hypogonadism among all study participants was 18.5%. The prevalence of Hypogonadism in diabetic and non-diabetic men was 24.3% and 8.3%, respectively. The mean (SD) total testosterone concentration of diabetic and non-diabetic men was 3.78 ng/ml (1.7) and 4.92 ng/ml (2.5), respectively (P- value <0.005). In response to (ADAM) questionnaire, 19.8% of diabetics and 3% of the non-diabetics had symptomatic androgen deficiency (P value <0.005). Hypogonadism and symptomatic androgen deficiency were negatively and significantly related to diabetes, monthly income and age (P value <0.005).
Hypogonadism is a prevalent disorder among Jordanian diabetic population. Symptoms of androgen deficiency should be corroborated with testosterone level to establish a multidisciplinary approach for management of hypogonadism.
确定约旦糖尿病男性和非糖尿病男性性腺功能减退的患病率。
对1717名男性进行横断面研究（1089名2型糖尿病参与者和628名非糖尿病受试者）。两组均被要求回答老年男性雄激素缺乏（ADAM）问卷。测量清晨总睾酮、催乳素、性激素结合球蛋白、促卵泡生成素、促黄体生成素、糖化血红蛋白和空腹血糖。性腺功能减退定义为总睾酮<3 ng/ml且计算得出的游离睾酮<5 ng/dl。
所有研究参与者中性腺功能减退的患病率为18.5%。糖尿病男性和非糖尿病男性中性腺功能减退的患病率分别为24.3%和8.3%。糖尿病男性和非糖尿病男性的平均（标准差）总睾酮浓度分别为3.78 ng/ml（1.7）和4.92 ng/ml（2.5）（P值<0.005）。对于（ADAM）问卷的回答，19.8%的糖尿病患者和3%的非糖尿病患者有症状性雄激素缺乏（P值<0.005）。性腺功能减退和症状性雄激素缺乏与糖尿病、月收入和年龄呈负相关且具有显著相关性（P值<0.005）。
性腺功能减退在约旦糖尿病患者中是一种普遍存在的疾病。雄激素缺乏的症状应通过睾酮水平得到证实，以建立多学科方法来管理性腺功能减退。
