肥胖和中度至剧烈身体活动不足预示着成人心血管代谢异常。
Adiposity and insufficient MVPA predict cardiometabolic abnormalities in adults.
作者信息
Peterson Mark D, Al Snih Soham, Stoddard Jonathan, McClain James, Lee I-Min
机构信息
1Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI; 2Division of Rehabilitation Sciences/School of Health Professions, Department of Internal Medicine/Division of Geriatrics, University of Texas Medical Branch, Galveston, TX; 3Division of Cancer Control and Population Sciences-National Cancer Institute, National Institutes of Health, Bethesda, MD; and 4Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
出版信息
Med Sci Sports Exerc. 2014 Jun;46(6):1133-9. doi: 10.1249/MSS.0000000000000212.
OBJECTIVES
The purpose of this study is to compare the extent to which different combinations of objectively measured sedentary behavior (SB) and physical activity contribute to cardiometabolic health.
DESIGN AND METHODS
A population representative sample of 5268 individuals, ages 20-85 yr, was included from the combined 2003-2006 National Health and Nutrition Examination Survey datasets. Activity categories were created on the combined basis of objectively measured SB and moderate-to-vigorous physical activity (MVPA) tertiles. Cardiometabolic abnormalities included elevated blood pressure, levels of triglycerides, fasting plasma glucose, C-reactive protein, homeostasis model assessment of insulin resistance value, and low HDL cholesterol level. Body mass index and dual-energy x-ray absorptiometry-derived percent body fat and android adiposity were also compared across groups. Predictors for a metabolically abnormal phenotype (≥3 cardiometabolic abnormalities or insulin resistance) were determined.
RESULTS
Adults with the least SB and greatest MVPA exhibited the healthiest cardiometabolic profiles, whereas adults with the greatest SB and lowest MVPA were older and had elevated risk. Time spent in SB was not a predictor of the metabolically abnormal phenotype when MVPA was accounted for. Adults with the highest MVPA across SB tertiles did not differ markedly in prevalence of obesity, adiposity, and/or serum cardiometabolic risk factors; however, less MVPA was associated with substantial elevations of obesity and cardiometabolic risk. Android adiposity (per kilogram) was independently associated with the metabolically abnormal phenotype in both men (odds ratio, 2.36 (95% CI, 1.76-3.17), P < 0.001) and women (odds ratio, 2.00 (95% CI, 1.63-2.45), P < 0.001). Among women, greater SB and less lifestyle moderate activity and MVPA were each independently associated with the metabolically abnormal phenotype, whereas only less MVPA was associated with it in men.
CONCLUSIONS
MVPA is a strong predictor of cardiometabolic health among adults, independent of time spent in SB.
目的
本研究旨在比较客观测量的久坐行为（SB）和身体活动的不同组合对心脏代谢健康的影响程度。
设计与方法
纳入2003 - 2006年全国健康与营养检查调查数据集合并后的5268名20 - 85岁的具有人群代表性的样本。根据客观测量的SB和中度至剧烈身体活动（MVPA）三分位数综合创建活动类别。心脏代谢异常包括血压升高、甘油三酯水平、空腹血糖、C反应蛋白、胰岛素抵抗稳态模型评估值以及低高密度脂蛋白胆固醇水平。还比较了各组的体重指数、双能X线吸收法得出的体脂百分比和腹部肥胖情况。确定代谢异常表型（≥3种心脏代谢异常或胰岛素抵抗）的预测因素。
结果
SB最少且MVPA最多的成年人表现出最健康的心脏代谢特征，而SB最多且MVPA最少的成年人年龄较大且风险升高。当考虑MVPA时，SB所花费的时间不是代谢异常表型的预测因素。在SB三分位数中MVPA最高的成年人在肥胖、肥胖程度和/或血清心脏代谢危险因素的患病率方面没有显著差异；然而，MVPA较少与肥胖和心脏代谢风险的大幅升高相关。腹部肥胖（每千克）在男性（优势比，2.36（95%CI，1.76 - 3.17），P < 0.001）和女性（优势比，2.00（95%CI，1.63 - 2.45），P < 0.001）中均与代谢异常表型独立相关。在女性中，更多的SB、更少的生活方式适度活动和MVPA各自独立与代谢异常表型相关，而在男性中只有更少的MVPA与之相关。
结论
MVPA是成年人心脏代谢健康的有力预测因素，独立于SB所花费的时间。
Zotero 插件