Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York.
Department of Biostatistics, Collaborating Studies Coordinating Center, University of North Carolina, Chapel Hill, North Carolina.
J Clin Endocrinol Metab. 2018 Sep 1;103(9):3289-3298. doi: 10.1210/jc.2018-00356.
Time spent in moderate-to-vigorous physical activity (MVPA), but not in sedentary behavior (SB), is related to cardiometabolic risk among non-Hispanic white youth.
Examine associations of SB and MVPA with cardiometabolic risk factors among Hispanic/Latino youth.
Cross-sectional analysis.
Four US communities.
Hispanic/Latino youth (N = 1,426) ages 8 to 16 years.
Associations of MVPA and SB, measured using 7-day accelerometer data (independent variables), with markers of glucose and lipid metabolism, inflammation, and endothelial function (dependent variables), were assessed in multivariable linear regression models while adjusting for sociodemographic characteristics and accelerometer wear time. Additional models controlled for obesity measures.
SB comprised a mean (SD) of 75% (13%) of accelerometer wear time; mean (SD) time of MVPA was 35 min/d (22 min/d). Deleterious levels of high-density lipoprotein-cholesterol (HDL-C), triglycerides, insulin resistance, C-reactive protein, and plasminogen activator inhibitor-1 were associated with lower levels of MVPA and higher levels of SB (all P < 0.05). Associations of MVPA with log-transformed triglyceride concentrations (β per 15-min/d increment, -0.039; SE, 0.018; P = 0.037) and SB with HDL-C (β per 30-min/d increment, -0.63; SE, 0.26; P = 0.018), but not those with other markers, remained significant after adjusting for MVPA or SB and further adjustment for body mass index and waist circumference. Higher SB tertiles were associated with lower soluble receptor for advanced glycation end products in fully adjusted models (P for trend = 0.037).
Physiological precursors of diabetes and cardiovascular disease were associated with MVPA and SB among US Hispanic/Latino youth, a group that bears a disproportionate burden of metabolic disorders.
非西班牙裔白人群体中，中等至剧烈强度的身体活动（MVPA）时间与心血管代谢风险有关，但与久坐行为（SB）无关。
研究西班牙裔/拉丁裔青少年的 SB 和 MVPA 与心血管代谢风险因素的关联。
横断面分析。
美国四个社区。
8 至 16 岁的西班牙裔/拉丁裔青少年（N=1426）。
使用 7 天加速度计数据（自变量）评估 MVPA 和 SB 与葡萄糖和脂质代谢标志物、炎症和内皮功能（因变量）之间的关联，在多变量线性回归模型中进行调整，同时调整社会人口统计学特征和加速度计佩戴时间。其他模型控制肥胖指标。
SB 占加速度计佩戴时间的 75%（13%）；MVPA 的平均（SD）时间为 35 分钟/天（22 分钟/天）。高密度脂蛋白胆固醇（HDL-C）、甘油三酯、胰岛素抵抗、C 反应蛋白和纤溶酶原激活物抑制剂-1的有害水平与较低水平的 MVPA 和较高水平的 SB 相关（均 P <0.05）。MVPA 与经对数转换的甘油三酯浓度呈负相关（每增加 15 分钟/天的增量，-0.039；SE，0.018；P=0.037），SB 与 HDL-C 呈正相关（每增加 30 分钟/天的增量，-0.63；SE，0.26；P=0.018），但在调整 MVPA 或 SB 后，以及进一步调整体重指数和腰围后，与其他标志物的关联仍然显著。在完全调整模型中，较高的 SB 三分位数与可溶性晚期糖基化终产物受体降低相关（趋势 P=0.037）。
糖尿病和心血管疾病的生理前体与美国西班牙裔/拉丁裔青少年的 MVPA 和 SB 相关，这一群体代谢紊乱的负担不成比例。
