雅拉敏：血管紧张素家族的新成员。
Alamandine: a new member of the angiotensin family.
机构信息
aNational Institute of Science and Technology in Nanobiopharmaceutics, Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais bInstituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia, Rio Grande do Sul, Brazil.
出版信息
Curr Opin Nephrol Hypertens. 2014 Mar;23(2):130-4. doi: 10.1097/01.mnh.0000441052.44406.92.
PURPOSE OF REVIEW
In this article, we review the recent findings regarding a new derivative of angiotensin-(1-7) [Ang-(1-7)], alamandine, and its receptor, the Mas-related G-coupled receptor type D (MrgD) with a special emphasis on its role and how it can be formed.
RECENT FINDINGS
Over the last decade, there have been significant conceptual changes regarding the understanding of the renin-angiotensin system (RAS). A cardioprotective axis has been elucidated by the discovery of the Mas receptor for the biologically active Ang-(1-7), and the angiotensin-converting enzyme 2 (ACE2) that coverts Ang II into Ang-(1-7). In addition, several components of the system, such as Ang-(1-12), Angiotensin A (Ang A) and the newly discovered peptide, alamandine, have been identified. Alamandine is generated by catalysis of Ang A via ACE2 or directly from Ang-(1-7).
SUMMARY
Alamandine is a vasoactive peptide with similar protective actions as Ang-(1-7) that acts through the MrgD and may represent another important counter-regulatory mechanism within the RAS.
目的综述
本文综述了血管紧张素-(1-7) [Ang-(1-7)]的一种新衍生物alamandine 及其受体 MrgD（Mas 相关 G 蛋白偶联受体 D）的最新研究发现，重点介绍其作用及其形成方式。
最近的发现
在过去的十年中，人们对肾素-血管紧张素系统 (RAS) 的理解发生了重大概念变化。Mas 受体是生物活性 Ang-(1-7) 的受体，血管紧张素转换酶 2 (ACE2) 将 Ang II 转化为 Ang-(1-7)，由此阐明了一个心脏保护轴。此外，系统的几个组成部分，如 Ang-(1-12)、血管紧张素 A (Ang A) 和新发现的肽 alamandine，已经被确定。alamandine 通过 ACE2 或直接从 Ang-(1-7) 催化 Ang A 生成。
总结
alamandine 是一种血管活性肽，具有与 Ang-(1-7) 相似的保护作用，通过 MrgD 发挥作用，可能代表 RAS 内另一个重要的代偿调节机制。
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