aNational Institute of Science and Technology in Nanobiopharmaceutics, Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais bInstituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia, Rio Grande do Sul, Brazil.
Curr Opin Nephrol Hypertens. 2014 Mar;23(2):130-4. doi: 10.1097/01.mnh.0000441052.44406.92.
In this article, we review the recent findings regarding a new derivative of angiotensin-(1-7) [Ang-(1-7)], alamandine, and its receptor, the Mas-related G-coupled receptor type D (MrgD) with a special emphasis on its role and how it can be formed.
Over the last decade, there have been significant conceptual changes regarding the understanding of the renin-angiotensin system (RAS). A cardioprotective axis has been elucidated by the discovery of the Mas receptor for the biologically active Ang-(1-7), and the angiotensin-converting enzyme 2 (ACE2) that coverts Ang II into Ang-(1-7). In addition, several components of the system, such as Ang-(1-12), Angiotensin A (Ang A) and the newly discovered peptide, alamandine, have been identified. Alamandine is generated by catalysis of Ang A via ACE2 or directly from Ang-(1-7).
Alamandine is a vasoactive peptide with similar protective actions as Ang-(1-7) that acts through the MrgD and may represent another important counter-regulatory mechanism within the RAS.
本文综述了血管紧张素-(1-7) [Ang-(1-7)]的一种新衍生物alamandine 及其受体 MrgD（Mas 相关 G 蛋白偶联受体 D）的最新研究发现，重点介绍其作用及其形成方式。
在过去的十年中，人们对肾素-血管紧张素系统 (RAS) 的理解发生了重大概念变化。Mas 受体是生物活性 Ang-(1-7) 的受体，血管紧张素转换酶 2 (ACE2) 将 Ang II 转化为 Ang-(1-7)，由此阐明了一个心脏保护轴。此外，系统的几个组成部分，如 Ang-(1-12)、血管紧张素 A (Ang A) 和新发现的肽 alamandine，已经被确定。alamandine 通过 ACE2 或直接从 Ang-(1-7) 催化 Ang A 生成。
alamandine 是一种血管活性肽，具有与 Ang-(1-7) 相似的保护作用，通过 MrgD 发挥作用，可能代表 RAS 内另一个重要的代偿调节机制。
