Hassani Bahareh, Attar Zeinab, Firouzabadi Negar
Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Recombinant Proteins Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran.
Cancer Cell Int. 2023 Oct 27;23(1):254. doi: 10.1186/s12935-023-03080-9.
The renin-angiotensin-aldosterone system (RAAS), is an old system with new fundamental roles in cancer biology which influences cell growth, migration, death, and metastasis. RAAS signaling enhances cell proliferation in malignancy directly and indirectly by affecting tumor cells and modulating angiogenesis. Cancer development may be influenced by the balance between the ACE/Ang II/AT1R and the ACE2/Ang 1-7/Mas receptor pathways. The interactions between Ang II/AT1R and Ang I/AT2R as well as Ang1-7/Mas and alamandine/MrgD receptors in the RAAS pathway can significantly impact the development of cancer. Ang I/AT2R, Ang1-7/Mas, and alamandine/MrgD interactions can have anticancer effects while Ang II/AT1R interactions can be involved in the development of cancer. Evidence suggests that inhibitors of the RAAS, which are conventionally used to treat cardiovascular diseases, may be beneficial in cancer therapies.Herein, we aim to provide a thorough description of the elements of RAAS and their molecular play in cancer. Alongside this, the role of RAAS components in sex-dependent cancers as well as GI cancers will be discussed with the hope of enlightening new venues for adjuvant cancer treatment.
肾素-血管紧张素-醛固酮系统（RAAS）是一个在癌症生物学中具有新的重要作用的古老系统，它影响细胞生长、迁移、死亡和转移。RAAS信号传导通过影响肿瘤细胞和调节血管生成直接或间接地增强恶性肿瘤中的细胞增殖。癌症的发展可能受血管紧张素转换酶/血管紧张素II/血管紧张素II 1型受体（ACE/Ang II/AT1R）与血管紧张素转换酶2/血管紧张素1-7/ Mas受体途径之间平衡的影响。RAAS途径中血管紧张素II/AT1R与血管紧张素I/血管紧张素II 2型受体（Ang I/AT2R）以及血管紧张素1-7/Mas与阿兰曼丁/MrgD受体之间的相互作用可显著影响癌症的发展。Ang I/AT2R、血管紧张素1-7/Mas和阿兰曼丁/MrgD之间的相互作用可产生抗癌作用，而血管紧张素II/AT1R之间的相互作用可能参与癌症的发展。有证据表明，传统上用于治疗心血管疾病的RAAS抑制剂可能对癌症治疗有益。在此，我们旨在全面描述RAAS的组成部分及其在癌症中的分子作用。与此同时，将讨论RAAS成分在性别依赖性癌症以及胃肠道癌症中的作用，以期为辅助癌症治疗开辟新途径。
