Ohtsu Kensei, Matsui Toshiyuki, Nishimura Taku, Hirai Fumihito, Ikeda Keisuke, Iwashita Akinori, Yorioka Makoto, Hatakeyama Sadamune, Hoashi Toshio, Koga Yuki, Sakurai Toshihiro, Miyaoka Masaki
Department of Gastroenterology, Fukuoka University Chikushi Hospital.
Nihon Shokakibyo Gakkai Zasshi. 2014 Jan;111(1):61-8.
Mesenteric phlebosclerosis (MP) is a relatively rare disease of the colon. An association between MP and Chinese herbal medicine intake has recently been recognized.
In the present study, we investigated the association between MP and Chinese herbal medicine intake in 42 patients, including those reported in the literature as well as those treated by us.
Approximately 90% patients treated by us reported a history of Chinese herbal medicine intake, particularly kamishoyosan, orengedokuto, and sanshishi (gardeniae fructus), the lattermost being consumed by the majority of patients as a crude herbal medicine.
Several MP patients report a history of Chinese herbal medicine intake. Furthermore, symptoms are exacerbated in MP patients who continue to consume the medicine after onset. Interestingly, MP was reported to develop in a married couple who had consumed the same Chinese herbal medicine for a prolonged period. These findings suggest that the intake of Chinese herbal medicine, particularly sanshishi, is strongly associated with MP development.
肠系膜静脉硬化（MP）是一种相对罕见的结肠疾病。最近人们认识到MP与服用中草药之间存在关联。
在本研究中，我们调查了42例患者中MP与服用中草药之间的关联，其中包括文献报道的患者以及我们治疗的患者。
我们治疗的患者中约90%报告有服用中草药的历史，尤其是加味逍遥散、温经汤和栀子，大多数患者将栀子作为生草药服用。
一些MP患者报告有服用中草药的历史。此外，发病后继续服药的MP患者症状会加重。有趣的是，据报道一对长期服用相同中草药的夫妇患上了MP。这些发现表明，服用中草药，尤其是栀子，与MP的发生密切相关。
