Division of Neonatology/Pulmonary Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati.
Division of Immunobiology, The Perinatal Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio.
Semin Reprod Med. 2014 Jan;32(1):56-67. doi: 10.1055/s-0033-1361823. Epub 2014 Jan 3.
Chorioamnionitis is a frequent cause of preterm birth and is associated with an increased risk for injury responses in the lung, gastrointestinal tract, brain, and other fetal organs. Chorioamnionitis is a polymicrobial nontraditional infectious disease because the organisms causing chorioamnionitis are generally of low virulence and colonize the amniotic fluid often for extended periods, and the host (mother and the fetus) does not have typical infection-related symptoms such as fever. In this review, we discuss the effects of chorioamnionitis in experimental animal models that mimic the human disease. Our focus is on the immune changes in multiple fetal organs and the pathogenesis of chorioamnionitis-induced injury in different fetal compartments. As chorioamnionitis disproportionately affects preterm infants, we discuss the relevant developmental context for the immune system. We also provide a clinical context for the fetal responses.
绒毛膜羊膜炎是早产的常见原因，并与肺部、胃肠道、大脑和其他胎儿器官的损伤反应风险增加有关。绒毛膜羊膜炎是一种多微生物非传统感染性疾病，因为引起绒毛膜羊膜炎的病原体通常毒性较低，并在羊水中长期定植，而宿主（母亲和胎儿）没有典型的与感染相关的症状，如发热。在这篇综述中，我们讨论了在模拟人类疾病的实验动物模型中绒毛膜羊膜炎的影响。我们的重点是多种胎儿器官的免疫变化以及不同胎儿隔室中绒毛膜羊膜炎诱导损伤的发病机制。由于绒毛膜羊膜炎不成比例地影响早产儿，我们讨论了免疫系统的相关发育背景。我们还为胎儿反应提供了临床背景。
