Chernousov M A, Faerman A I, Frid M G, Koteliansky V E
FEBS Lett. 1987 Jun 8;217(1):124-8. doi: 10.1016/0014-5793(87)81255-3.
A monoclonal antibody L8 specific to fibronectin was shown to inhibit fibronectin incorporation into the fibroblast extracellular matrix. Antibody L8 could not interact with fibronectin complexed with gelatin. The results suggest the existence of a specific site on the fibronectin molecule playing a critical role in the assembly of the fibronectin extracellular matrix. This site is located near the collagen-binding domain.
一种对纤连蛋白具有特异性的单克隆抗体L8被证明可抑制纤连蛋白掺入成纤维细胞的细胞外基质。抗体L8不能与与明胶复合的纤连蛋白相互作用。结果表明纤连蛋白分子上存在一个特定位点，该位点在纤连蛋白细胞外基质的组装中起关键作用。此位点位于胶原结合域附近。
