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1例对氟尿嘧啶、亚叶酸钙、奥沙利铂联合贝伐单抗治疗有效的局部进展期结直肠癌伴脓肿病例

[A case of locally advanced colorectal cancer with abscess responding to 5-fluorouracil, leucovorin, and oxaliplatin plus bevacizumab].

作者信息

Kuwabara Hiroshi, Watanabe Shuichi, Liu Bo, Mitsuoka Akito, Sanada Takahiro, Nakajima Kazumi, Goseki Narihide

机构信息

Dept. of Surgery, Shuuwa General Hospital.

出版信息

Gan To Kagaku Ryoho. 2013 Nov;40(12):2032-4.

Abstract

We encountered a case of colorectal cancer with pelvic abscess treated with radical surgery following colostomy and chemotherapy. The patient was a man in his 60s with advanced rectal cancer. The tumor had expanded locally and formed an abscess. We evaluated the primary lesion as unresectable, and performed chemotherapy with 5-fluorouracil, Leucovorin, and oxaliplatin( mFOLFOX) plus bevacizumab after colostomy. After 13 courses of chemotherapy, the tumor shrank remarkably. We performed a low anterior resection followed by adjuvant chemotherapy with capecitabine. The patient has had no recurrence for 18 months after surgery.

摘要

我们遇到了一例患有盆腔脓肿的结肠直肠癌患者,该患者在结肠造口术和化疗后接受了根治性手术。患者为一名60多岁的男性,患有晚期直肠癌。肿瘤已局部扩散并形成脓肿。我们评估原发灶无法切除,在结肠造口术后用5-氟尿嘧啶、亚叶酸钙和奥沙利铂(mFOLFOX)联合贝伐单抗进行化疗。经过13个疗程的化疗后,肿瘤明显缩小。我们进行了低位前切除术,随后用卡培他滨进行辅助化疗。患者术后18个月无复发。

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