Nakayasu Yasuyo, Yoshimatsu Kazuhiko, Yokomizo Hajime, Osawa Gakuji, Yano Yuki, Nakayama Mao, Sakuma Akiko, Yamaguchi Kentaro, Shiozawa Shunichi, Shimakawa Takeshi, Katsube Takao, Naritaka Yoshihiko
Dept. of Surgery, Tokyo Women's Medical University, Medical Center East.
Gan To Kagaku Ryoho. 2013 Nov;40(12):2029-31.
Case1: A 63-year-old woman with diarrhea and hematochezia was diagnosed as having rectal cancer invading the pelvis. Six courses of the 5-fluorouracil, leucovorin, and oxaliplatin( mFOLFOX6) plus panitumumab regimen were administered after sigmoid colostomy, following which low anterior resection was performed. Since the 6 courses of mFOLFOX6 were administered postoperatively, no evidence of recurrence has been observed for 18 months. Case2: A 52-year-old man with high fever and abdominal pain was diagnosed as having rectal cancer invading the bladder with a vesicorectal fistula. After transverse colostomy and 6 courses of mFOLFOX6 plus panitumumab, high anterior resection with partial cystectomy was performed. Since the 8 courses of capecitabine plus oxaliplatin (XELOX) were administered postoperatively, no evidence of recurrence has been observed for 12 months. Although no consensus has been reached pertaining to the use of neoadjuvant chemotherapy for the treatment of colorectal cancer, we could, in this study, demonstrate the efficacy of neoadjuvant chemotherapy with panitumumab for the treatment of locally advanced colorectal cancer.
病例1：一名63岁腹泻伴便血的女性被诊断为直肠癌侵犯盆腔。在乙状结肠造口术后给予6个疗程的5-氟尿嘧啶、亚叶酸钙和奥沙利铂（mFOLFOX6）联合帕尼单抗方案，随后进行低位前切除术。由于mFOLFOX6的6个疗程是在术后给予的，18个月来未观察到复发迹象。病例2：一名52岁高热伴腹痛的男性被诊断为直肠癌侵犯膀胱并伴有膀胱直肠瘘。在横结肠造口术和6个疗程的mFOLFOX6联合帕尼单抗治疗后，进行了高位前切除术并部分膀胱切除术。由于术后给予了8个疗程的卡培他滨加奥沙利铂（XELOX），12个月来未观察到复发迹象。尽管对于新辅助化疗用于治疗结直肠癌尚未达成共识，但在本研究中，我们能够证明帕尼单抗新辅助化疗治疗局部晚期结直肠癌的疗效。
