Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.
J Geriatr Psychiatry Neurol. 2014 Mar;27(1):13-23. doi: 10.1177/0891988713516540. Epub 2014 Jan 5.
Molecular imaging represents a bridge between basic and clinical neuroscience observations and provides many opportunities for translation and identifying mechanisms that may inform prevention and intervention strategies in late-life depression (LLD). Substantial advances in instrumentation and radiotracer chemistry have resulted in improved sensitivity and spatial resolution and the ability to study in vivo an increasing number of neurotransmitters, neuromodulators, and, importantly, neuropathological processes. Molecular brain imaging studies in LLD will be reviewed, with a primary focus on positron emission tomography. Future directions for the field of molecular imaging in LLD will be discussed, including integrating molecular imaging with genetic, neuropsychiatric, and cognitive outcomes and multimodality neuroimaging.
分子影像学是基础神经科学和临床神经科学观察之间的桥梁，为转化研究和识别机制提供了许多机会，这些机制可能为老年期抑郁症（LLD）的预防和干预策略提供信息。仪器设备和放射性示踪剂化学的显著进步提高了灵敏度和空间分辨率，使人们能够越来越多地在体内研究神经递质、神经调质，以及重要的神经病理过程。本文将对 LLD 的分子脑影像学研究进行综述，重点是正电子发射断层扫描。本文还将讨论 LLD 分子影像学领域的未来发展方向，包括将分子影像学与遗传、神经精神和认知结果以及多模态神经影像学相结合。
