凝血因子IX基因内的MspI多态性位点。该位点的定位及一种改进的检测方法。
MspI polymorphic site within the factor IX gene. Localization of the site and an improved method for detection.
作者信息
Freedenberg D L, Chen S H, Kurachi K, Scott C R
出版信息
Hum Genet. 1987 Jul;76(3):262-4. doi: 10.1007/BF00283620.
PMID:2439437
Abstract
We have localized the position of the MspI polymorphic site that exists within the factor IX gene. The location of the MspI polymorphic site is within intron D, 1.9 kb upstream from the beginning of exon V and 4 kb downstream from a known polymorphic TaqI site. The use of a specific genomic probe simplifies the interpretation of the MspI polymorphism by reducing the number of non-overlaping DNA fragments to three bands; 2.4, 3.4, and 5.8 kb.
摘要
我们已经定位了存在于凝血因子IX基因内的MspI多态性位点的位置。MspI多态性位点位于内含子D内，在外显子V起始位置上游1.9 kb处，且在一个已知的多态性TaqI位点下游4 kb处。使用一种特定的基因组探针，通过将不重叠的DNA片段数量减少到三条带（2.4、3.4和5.8 kb），简化了MspI多态性的解读。
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