Department of Pathophysiology, Basic Medical Science of Dalian Medical University, Dalian 116044, China; Institute of Cancer Stem Cell, Dalian Medical University Cancer Center, Dalian 116044, China.
Department of Pathophysiology, Basic Medical Science of Dalian Medical University, Dalian 116044, China.
Exp Cell Res. 2014 Apr 15;323(1):1-6. doi: 10.1016/j.yexcr.2013.12.025. Epub 2014 Jan 4.
The miR-92a family, including miR-25, miR-92a-1, miR-92a-2 and miR-363, arises from three different paralog clusters miR-17-92, miR-106a-363, and miR-106b-25 that are highly conservative in the process of evolution, and it was thought as a group of microRNAs (miRNAs) correlated with endothelial cells. Aberrant expression of miR-92a family was detected in multiple cancers, and the disturbance of miR-92a family was related with tumorigenesis and tumor development. In this review, the progress on the relationship between miR-92a family and their target genes and malignant tumors will be summarized.
miR-92a 家族，包括 miR-25、miR-92a-1、miR-92a-2 和 miR-363，来自三个不同的基因簇 miR-17-92、miR-106a-363 和 miR-106b-25，这些基因簇在进化过程中高度保守，被认为是一组与内皮细胞相关的 microRNAs（miRNAs）。miR-92a 家族的异常表达在多种癌症中被检测到，miR-92a 家族的紊乱与肿瘤发生和肿瘤发展有关。本综述总结了 miR-92a 家族及其靶基因与恶性肿瘤之间关系的研究进展。
