Deputy of Research and Technology, Ardabil University of Medical Sciences, Ardabil, Iran.
Molecular Medicine Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran.
Pathol Res Pract. 2020 Nov;216(11):153220. doi: 10.1016/j.prp.2020.153220. Epub 2020 Sep 22.
MicroRNAs (miRNAs) are single-stranded non-coding RNAs that regulate gene expression post-transcriptionally via mRNA degradation, or translational repression. They have important roles in normal development and homeostasis maintenance. Many studies have revealed that aberrant expression of miRNAs is associated with development of pathological conditions, including cancers. MiRNAs can either promote or suppress tumorigenesis based on the regulation of gene expression by targeting multiple molecules. In recent years, several miRNAs have been reported to be dysregulated in various cancers. Most recent findings have shown that miR-142 gene, located at chromosome 17q22, is involved in cellular migration, proliferation, and apoptosis in different human cancers. The present review discusses some molecular mechanisms and the expression status of miRNA-142 in the pathogenesis of various cancers.
MicroRNAs (miRNAs) 是单链非编码 RNA，通过 mRNA 降解或翻译抑制来进行转录后基因表达调控。它们在正常发育和维持内稳态中发挥着重要作用。许多研究表明，miRNAs 的异常表达与包括癌症在内的病理状况的发展有关。miRNAs 可以通过靶向多个分子来调节基因表达，从而促进或抑制肿瘤发生。近年来，已有研究报道多种 miRNAs 在各种癌症中失调。最近的研究结果表明，位于染色体 17q22 上的 miR-142 基因参与了不同人类癌症中的细胞迁移、增殖和凋亡。本综述讨论了 miRNA-142 在各种癌症发病机制中的一些分子机制和表达状态。
