Vejerslev L O, Nørgaard-Pedersen B
Hum Reprod. 1987 Apr;2(3):237-40. doi: 10.1093/oxfordjournals.humrep.a136520.
The alpha-fetoprotein (AFP) content of chorionic villi from elective and spontaneous abortuses, diploid androgenetic and paternally derived triploid conceptuses was measured by a radioimmunoassay technique and related to the presence of fetal parts and chromosome constitution. AFP values above 10 kIU/l were detected in villi from all chromosomally normal conceptuses, except for one without fetal parts, and also in nine out of 13 triploid conceptuses and 19 out of 27 diploid androgenetic conceptuses. Early fetal demise may explain villous AFP concentrations below 10 kIU/l in one karyotypically normal and four triploid abortuses. The finding of immunoreactive, genuine AFP in diploid androgenetic molar conceptuses, assumed to be anembryonic, indicates AFP synthesis by abnormal trophoblastic tissue and intravesicular accumulation of AFP.
采用放射免疫分析技术测定了选择性流产和自然流产的绒毛、二倍体孤雄生殖及父源三倍体孕体中α-甲胎蛋白（AFP）的含量，并将其与胎儿组织的存在及染色体组成相关联。在所有染色体正常的孕体绒毛中，除了一个没有胎儿组织的孕体，均检测到AFP值高于10 kIU/l；在13个三倍体孕体中有9个、27个二倍体孤雄生殖孕体中有19个也检测到AFP值高于10 kIU/l。早期胎儿死亡可能解释了一个核型正常和四个三倍体流产孕体中绒毛AFP浓度低于10 kIU/l的情况。在假定无胚胎的二倍体孤雄生殖葡萄胎孕体中发现具有免疫反应性的真正AFP，表明异常滋养层组织可合成AFP并在囊内蓄积。
