Yoshimatsu N, Hoshi K, Sato A, Munakata S, Fukushima T
Nihon Sanka Fujinka Gakkai Zasshi. 1987 Jun;39(6):918-24.
The presence of the fetal component is an important factor in explaining the mechanism of the occurrence of the hydatidiform mole. But we have not confirmed in which phase the fertilized becomes a fetus. Therefore the mechanism of the occurrence of hydatidiform mole was investigated, using alpha-fetoprotein (AFP) produced in the fetal liver and the yolk sac, as a parameter. Total hydatidiform moles, partial hydatidiform moles, chorionic villi obtained from normal pregnancy artificially terminated and spontaneous abortion, and also the fetal liver, umbilical cord, and intestine were examined. Paraffin sections of these materials were examined for the presence of AFP by a peroxidase-anti-peroxidase method.
In the fetal liver, the gelatinous area of the umbilical cord the lamina propria mucosae of the intestine, and the AFP were stained positive. In the interstitial area of the chorionic villi of normal pregnancy, the AFP was positive (78.3% n = 23). But in the villous epithelium, the AFP was negative. In the interstitial area of the chorionic villi of spontaneous abortion, the AFP was positive (88.9% n = 9). But in the villous epithelium, the AFP was negative. In the interstitial area of the partial hydatidiform mole, the AFP was positive (100% n = 6). In the epithelial area, the AFP was negative. No localization of the AFP was found in either the interstitial area or the epithelial area of the cyst of total hydatidiform mole (100% n = 7). We concluded that the AFP exuded to tissues derived from mesoblast by feto-chorionic circulation.(ABSTRACT TRUNCATED AT 250 WORDS)
胎儿成分的存在是解释葡萄胎发生机制的一个重要因素。但我们尚未证实受精卵在哪一阶段发育成胎儿。因此，以胎儿肝脏和卵黄囊产生的甲胎蛋白（AFP）为参数，对葡萄胎的发生机制进行了研究。检查了完全性葡萄胎、部分性葡萄胎、人工流产和自然流产获取的正常妊娠绒毛，以及胎儿肝脏、脐带和肠道。采用过氧化物酶-抗过氧化物酶法对这些材料的石蜡切片进行AFP检测。
胎儿肝脏、脐带的胶状区域、肠黏膜固有层的AFP染色呈阳性。正常妊娠绒毛间质区域的AFP呈阳性（78.3%，n = 23）。但绒毛上皮的AFP呈阴性。自然流产绒毛间质区域的AFP呈阳性（88.9%，n = 9）。但绒毛上皮的AFP呈阴性。部分性葡萄胎间质区域的AFP呈阳性（100%，n = 6）。上皮区域的AFP呈阴性。完全性葡萄胎囊肿的间质区域或上皮区域均未发现AFP定位（100%，n = 7）。我们得出结论，AFP通过胎儿-绒毛循环渗出到中胚层来源的组织中。（摘要截短至250字）
